DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and IVNS1ABP

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_011507381.1	Gene:	IVNS1ABP / 10625	HGNCID:	16951	Length:	649	Species:	Homo sapiens

Alignment Length:	645	Identity:	174/645 - (26%)
Similarity:	293/645 - (45%)	Gaps:	103/645 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMA 73
            :.:.|.:::.:.....|......:|:.|:.|||.|:|......|||.|||...||.:.:|.::..
Human     2 IPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSD 66

  Fly    74 ESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRF 138
            ...|..:  |...:.|.|:|.|:||.|:.|::.|.:.|:::...|..|::..|:..|..:|:||.
Human    67 PHGISHV--KFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRM 129

  Fly   139 HPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEV 203
            ...:.:..|.||..|...:|::..|.||.::..::|:.||||.|. ...||:|..|.:.:.:...
Human   130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEVMLEDNVCLPSNGK 193

  Fly   204 IFEACMKWVK---------------------YAEDKR----------SELF-------------- 223
            ::...:.||:                     |:.|.:          :|:|
Human   194 LYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQVHI 258

  Fly   224 -------PQ-------------VLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLD------- 261
                   |:             .|::....:.||:.....||.|:...:::.|..:||
Human   259 AQSEKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIF 323

  Fly   262 -----------------------EAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTG 303
                                   |.:...|:.:....:|..|:...:.| ..|::.|.||. :..
Human   324 LHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAE-MNGKLIAAGGY-NRE 386

  Fly   304 ESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNG-TERLSTVEVYDPRKNKWS 367
            |.:.|||.|:|.|..|.....|...|:|..:|||.|:||..||.|| ::.||..|:||...:.|.
Human   387 ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWI 451

  Fly   368 QGCAMLCKRSAVGVAALDDCIYVCGGYD--GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQ 430
            ....:...|...||.||:..:|:.||.|  |...|...:|:.|.:..|.:.|.:...|....|.:
Human   452 PVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCE 516

  Fly   431 LNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLR 495
            |.||:|.:||.:..:..::||||:...:.|..::||...|...|||.||||::||||:.|:..:.
Human   517 LGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIS 581

  Fly   496 SVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWT 555
            .||.|||..:.||::..|...||...:|.....::|:||:||...|:|||||:.|:::|:
Human   582 CVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	32/105 (30%)
		PHA03098	36..510	CDD:222983	154/571 (27%)
		BACK	143..245	CDD:285009	28/166 (17%)
		Kelch	292..339	CDD:128874	17/46 (37%)
		KELCH repeat	329..372	CDD:276965	18/43 (42%)
		Kelch	340..386	CDD:128874	17/46 (37%)
		KELCH repeat	376..417	CDD:276965	14/42 (33%)
		Kelch	387..433	CDD:128874	13/47 (28%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		Kelch	435..480	CDD:128874	15/44 (34%)
		Kelch_1	469..514	CDD:279660	20/44 (45%)
		KELCH repeat	470..514	CDD:276965	20/43 (47%)
		Kelch_1	517..560	CDD:279660	16/39 (41%)
		KELCH repeat	517..560	CDD:276965	16/39 (41%)
IVNS1ABP	XP_011507381.1	BTB	22..126	CDD:279045	32/105 (30%)
		PHA03098	23..645	CDD:222983	172/624 (28%)
		BACK	134..229	CDD:197943	21/95 (22%)
		KELCH repeat	365..408	CDD:276965	14/44 (32%)
		Kelch	376..422	CDD:128874	17/46 (37%)
		KELCH repeat	416..458	CDD:276965	16/41 (39%)
		Kelch	423..470	CDD:128874	17/46 (37%)
		Kelch_1	460..506	CDD:279660	15/45 (33%)
		KELCH repeat	460..505	CDD:276965	15/44 (34%)
		KELCH repeat	509..552	CDD:276965	13/42 (31%)
		Kelch	521..566	CDD:128874	15/44 (34%)
		KELCH repeat	556..600	CDD:276965	20/43 (47%)
		Kelch	567..613	CDD:128874	17/45 (38%)
		Kelch_1	602..642	CDD:279660	16/40 (40%)
		KELCH repeat	603..642	CDD:276965	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820