Protein Alignment KLHL18 and gan

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_073786012.1
• Gene: gan / 100537435
• ZFINID: ZDB-GENE-121221-1
• Length: 609
• Species: Danio rerio
• Alignment Length: 548
• Identity: 141/548 - (25%)
• Similarity: 248/548 - (45%)
• Gaps: 53/548 - (9%)

  Fly    40 DVTLKVEDQTFSAHRVVLAATIPYFYAMFTNN--MAESRIKEITMKESAIEPSALESLINYVYSG 102
            |..|.:|.:.....:.:|||..||.......|  ..:..:.:|.::..|:  :.:..:::|::||
Zfish    39 DAVLVLEGEQIPVQKNILAAASPYIRTKLNYNPPKEDGSVYKIELQGIAV--TTMRQILDYIFSG 101

  Fly   103 QVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYID 167
            ::.:....:|:::..|..|.|::::..|..||.|.....|.:|||.|:.......:...|.:::.
Zfish   102 EITLSEDTIQDVVQAADLLLLTDLKSLCCQFLESCITAENCIGIRVFSLHYCLHHVYHVATEFLQ 166

  Fly   168 QNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRL 232
            .:|..|:.:||||....::|.||:..::|||..|..:.||.::|:.:..:.|.....:|::||.:
Zfish   167 THFRDVANTEEFLEQPPDRLCELLSMEKLNVGNERHVLEAVVRWIGHDTEARRVHMKEVMSAVWV 231

  Fly   233 PLLSPQFLADRVAREELIRS--SHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYA 295
            ..|...:|.:::..:.|:|.  .:.|.:.|..|..     :...||.:|:.|.     ::..|..
Zfish   232 QGLDQSYLQEQMLGDSLMREVIGNCCMESLGGAAQ-----QGEALLAAFKPRG-----YSECIVT 286

  Fly   296 VGGLASTGESVSTV-----EIYDPLTKKWKMGEQMSMMRSRVGVAVLN--GKLYAFGGFNGTER- 352
            |||...|....:.|     .:||...:.|.  :.|.|...|||..|::  |.::|.||.:..:.
Zfish   287 VGGEERTSRKPTAVARCMCPLYDRNRQLWI--DLMPMKERRVGHGVVSAEGYVFAIGGMDENKTV 349

  Fly   353 LSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTVEVYYPKSNTWKTV 416
            ||:.|.:||..|.|:|..:|:..|...|:|.||..|||.||.:..|. |.|:||:.|..|.|:.:
Zfish   350 LSSGEKFDPETNTWTQIPSMMQARQHFGIAELDGMIYVLGGENEDTEVLLTMEVFDPHCNVWRML 414

  Fly   417 AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGK 481
            .:|...|..|....:...:|.:||.....|:||||.||.....|..:.|:..||.......:..:
Zfish   415 PKMTTVRKFGSCATMKKRLYVMGGGSYGKIYDSVECYDPKTQQWTTVCPLKERRFGAVACGIGQE 479

  Fly   482 IYVCGG---------------YCGNSFLRSVECYDPQTDTWKLVTPMN-C---KRSRVALAANMG 527
            :||.||               .|.:.|      :..:...|.|:...| |   ..|.|..|..:|
Zfish   480 LYVFGGVRNRDADNPESSQMTICKSEF------FHDELKRWVLLDDQNLCIHTTSSFVYGAVPIG 538

  Fly   528 -KLWAIGGYDGESNLSTVEVYDPETDKW 554
             .::.:|..|..::...|..:...|..|
Zfish   539 ASIYVVGELDTGTSFDYVREFRRSTGTW 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	21/98 (21%)
		PHA03098	36..510	CDD:222983	129/497 (26%)
		KELCH repeat	329..372	CDD:276965	16/45 (36%)
		KELCH repeat	376..417	CDD:276965	18/41 (44%)
		KELCH repeat	423..466	CDD:276965	13/42 (31%)
		KELCH repeat	470..514	CDD:276965	9/58 (16%)
		Kelch_1	517..560	CDD:396078	9/39 (23%)
		KELCH repeat	517..560	CDD:276965	9/39 (23%)
gan	XP_073786012.1	None