Protein Alignment KLHL18 and PHOSPHO2-KLHL23

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001186219.1
• Gene: PHOSPHO2-KLHL23 / 100526832
• -ID: -
• Length: 558
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 167/571 - (29%)
• Similarity: 260/571 - (45%)
• Gaps: 40/571 - (7%)

  Fly    10 EDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQ-TFSAHRVVLAATIPYFYAMFTNNMA 73
            ||..:::|......:....|:.....|...|:||:.... .|..||.||||...||.||||.:|.
Human     7 EDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMK 71

  Fly    74 ESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRF 138
            |....:|  |.|.|....||.|:||.|:.|:.|..:|||:|:..|..||..:|:.||..||:...
Human    72 EKFKNKI--KLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHL 134

  Fly   139 HPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEV 203
            ...|.:|:.:||:..:|.:|...:.:.:...|.:|.|.||||.:..|:.|.::.|..|:|..||.
Human   135 DIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEA 199

  Fly   204 IFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVA-REELIRSSHQCRDLLDEAKDFH 267
            |.|..:||..:..:.|.|....:|:.:.:. :.|.:|...:. :...:.:.::.|.|:..|
Human   200 IIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALGLQRSCLLTENKIRSLIYNA---- 259

  Fly   268 LMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQM-SMMRSR 331
            |.|..:.:      .|||    |..:|.:||.  ....:|.|.|:||||..|..|.:: ...|..
Human   260 LNPMHKEI------SQRS----TATMYIIGGY--YWHPLSEVHIWDPLTNVWIQGAEIPDYTRES 312

  Fly   332 VGVAVLNGKLYAFGGF--NGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY 394
            .||..|...:|..||:  :..|.|.||.:|:...::|::|..||..|.......|..|:|..|||
Human   313 YGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGY 377

  Fly   395 DGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQ--LNGYVYALGGH---DGLSIFDSVERYD 454
            .........|.|.|....|..:|.|:|  ..|..|.  |:..:|.:|||   .|...:|.|:.|:
Human   378 RKGAPAEEAEFYDPLKEKWIPIANMIK--GVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYN 440

  Fly   455 QAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSR 519
            ...:.|..::...:....|.......|:|:.||.     ....|||||:.:.|:.:.||..:|..
Human   441 SDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWREIAPMMERRME 500

  Fly   520 VALAANMGKLWAIGGYDGESN--LSTVEVYDPETDKWTFMP--PMCAHSGG 566
            .......|.::..|||.....  |.::|.|||:.:||..:.  |....|.|
Human   501 CGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	44/117 (38%)
		PHA03098	36..510	CDD:222983	146/483 (30%)
		KELCH repeat	329..372	CDD:276965	14/44 (32%)
		KELCH repeat	376..417	CDD:276965	11/40 (28%)
		KELCH repeat	423..466	CDD:276965	12/47 (26%)
		KELCH repeat	470..514	CDD:276965	12/43 (28%)
		Kelch_1	517..560	CDD:396078	12/46 (26%)
		KELCH repeat	517..560	CDD:276965	12/46 (26%)
PHOSPHO2-KLHL23	NP_001186219.1	BTB_POZ_KLHL23	15..141	CDD:349561	45/127 (35%)
		PHA03098	45..545	CDD:222983	156/525 (30%)
		BACK_KLHL23	134..235	CDD:350537	28/101 (28%)
		KELCH repeat	310..355	CDD:276965	14/44 (32%)
		KELCH repeat	359..402	CDD:276965	12/42 (29%)
		KELCH repeat	406..495	CDD:276965	24/93 (26%)
		KELCH repeat	498..545	CDD:276965	12/46 (26%)