Protein Alignment KLHL18 and klhl31

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_002934899.1
• Gene: klhl31 / 100495906
• XenbaseID: XB-GENE-966130
• Length: 634
• Species: Xenopus tropicalis
• Alignment Length: 558
• Identity: 152/558 - (27%)
• Similarity: 268/558 - (48%)
• Gaps: 35/558 - (6%)

  Fly    19 DKLFGESFPLFKEIRRMGK---LCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEI 80
            |..:|.:  |.:.:.||.:   |||:|:..:.::|..|:||:|:...|||.:...:.:..|:
 Frog    52 DSSYGTT--LMEGMSRMRQDSFLCDLTIGTKTKSFMVHKVVMASCSEYFYDILKKDSSTQRV--- 111

  Fly    81 TMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLG 145
              ..:.|.|..|.::|.|.|:|::.:....:.:.:..|.:||::.:.:.|..||:...:..|.:.
 Frog   112 --DLNDISPLGLATVITYAYTGKITLSLYTIGSTISSAIYLQINALVNMCCDFLMQEMNVENCMY 174

  Fly   146 IRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMK 210
            :...|::...:...:||.|:|..||.:.|.:::||.|..:|:.||:..|.|.:.:|.|.|:..||
 Frog   175 VANIAETYGLKSTKEAAQKFIRDNFIEFSDTDQFLKLTFDQINELLIDDYLQLPSEIVAFQIAMK 239

  Fly   211 WVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGL 275
            |:.: ::||.:...::|:.:|...:|.|.|.:.|.....:.....|..||.||.::||:|..:..
 Frog   240 WLDF-DEKRIKYASELLSNIRFGTISAQDLVNYVQSVPRMMQDTDCHRLLVEAMNYHLLPYHQNT 303

  Fly   276 LQSFRTRQRSGEFFTGQIYAVGGLASTGE-SVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNG 339
            |||.||:.|.|   :..:..|||..:..| |:|...:|......||...::........|.|::|
 Frog   304 LQSRRTKIRGG---SRVLVTVGGRPALAEKSLSREILYRDPDGGWKRLAELPAKSFNQCVTVMDG 365

  Fly   340 KLYAFGGFNGTE-------RLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGV 397
            .||..||.:..:       .:|....||||.|.|.....|:.||:.......:..|:..||.:..
 Frog   366 FLYIAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLANMIQKRTHFSFNVFNGLIFAIGGRNSD 430

  Fly   398 TSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVW-- 460
            ..|.:||.|.|.:|.|:..|.:...|.....:.::|.:..:||:...:...||..||.:.|.|
 Frog   431 GGLASVECYVPSTNQWQMKAPLEVARCCHSSSIIDGKILVVGGYINNAYSRSVCMYDPSMDSWQD 495

  Fly   461 -VKMSPMLNRRCRLGVATLNGKIYVCGG-YCGNSFLR----SVECYDPQTDTWKLVTPMNCKRSR 519
             ..:|......|.:   ||..::||.|| ..|....|    .||||:|.|..|..|.|:....|.
 Frog   496 KANLSTPRGWHCSV---TLGDRVYVMGGSQLGGRGERVDVLPVECYNPHTGQWSYVAPLQNGVST 557

  Fly   520 VALAANMGKLWAIGGYD--GESNLSTVEVYDPETDKWT 555
            ...:...||::.:||::  .:.....::.|:|:.::||
 Frog   558 AGASTLNGKIYLVGGWNEVEKKYKKCIQCYNPDLNEWT 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	30/119 (25%)
		PHA03098	36..510	CDD:222983	136/492 (28%)
		KELCH repeat	329..372	CDD:276965	14/49 (29%)
		KELCH repeat	376..417	CDD:276965	11/40 (28%)
		KELCH repeat	423..466	CDD:276965	11/45 (24%)
		KELCH repeat	470..514	CDD:276965	18/48 (38%)
		Kelch_1	517..560	CDD:396078	9/41 (22%)
		KELCH repeat	517..560	CDD:276965	9/41 (22%)
klhl31	XP_002934899.1	BTB_POZ_KLHL31_KBTBD1	55..174	CDD:349569	31/125 (25%)
		PHA03098	73..612	CDD:222983	146/535 (27%)
		BACK_KLHL31_KBTBD1	167..264	CDD:350545	27/97 (28%)
		KELCH repeat	356..405	CDD:276965	14/48 (29%)
		KELCH repeat	409..453	CDD:276965	12/43 (28%)
		KELCH repeat	456..501	CDD:276965	10/44 (23%)
		KELCH repeat	503..551	CDD:276965	17/50 (34%)
		KELCH repeat	555..602	CDD:276965	9/41 (22%)