DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl5

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002938696.2	Gene:	klhl5 / 100494234	XenbaseID:	XB-GENE-968592	Length:	709	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	223/558 - (39%)
Similarity:	333/558 - (59%)	Gaps:	14/558 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            ::|...:...|..:||||.|...|:...|||:||::...||.||||:::.|::.:||.|:  .:|
Frog   159 QTFKRMENYLRHKQLCDVILIAGDRRIPAHRLVLSSVSDYFAAMFTSDVREAKQEEIKME--GVE 221

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            |:||.:|:.|.|:|::.:...|::.|:..|..||||.|.:||..||:.:.||.|.||||:|||:.
Frog   222 PNALWALVQYSYTGRLELKEDNIECLLSAACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQ 286

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            .|..|...|..|..::|.:|.:::|||.|...::.:|:..|::|:.:||.|..|.:.||::..::
Frog   287 GCTDLHKVAHNYTMEHFMEVIRNQEFLLLPAGEIAKLLASDDMNIPSEETILNALLTWVRHDVEQ 351

  Fly   219 RSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQ 283
            |.:...::||.:|||||:|||||| :....|.|...:|:.|:.||..:||:||||.:|||.||:.
Frog   352 RRKDLSKLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKP 415

  Fly   284 RSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFN 348
            |...  .|.::||||:.:| :..:::|.||..|..|.....|:..|.:.|||||..|||..||.:
Frog   416 RKST--VGVLFAVGGMDAT-KGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLEEKLYVVGGRD 477

  Fly   349 GTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTW 413
            |.:.|:|||.|:|:...|:....|...|..:|||.|:..:|..||:||.:.|||||.:.|::..|
Frog   478 GLKTLNTVECYNPKTKTWNVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 542

  Fly   414 KTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATL 478
            ..||.|...||..||..|:|.:||:||.||.|...|||.:|...:.|...|.|..||..:||.|.
Frog   543 NFVASMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCSQMSKRRGGVGVTTW 607

  Fly   479 NGKIYVCGGY---CGNSFLRSVEC---YDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDG 537
            ||.:|..||:   ..|...|..:|   |||:||.|..|..|:..|..|.:.....||:.:|||||
Frog   608 NGFLYAIGGHDAPASNLTSRLSDCVERYDPKTDVWTSVASMSISRDAVGVCLLGDKLYGVGGYDG 672

  Fly   538 ESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRIE 575
            :|.|:|||.|||:|::|..:.|:|.  |..||.|:.|:
Frog   673 QSYLNTVEAYDPQTNEWMQVAPLCL--GRAGACVVTIK 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	41/105 (39%)
		PHA03098	36..510	CDD:222983	193/479 (40%)
		BACK	143..245	CDD:285009	40/101 (40%)
		Kelch	292..339	CDD:128874	17/46 (37%)
		KELCH repeat	329..372	CDD:276965	19/42 (45%)
		Kelch	340..386	CDD:128874	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		Kelch	387..433	CDD:128874	20/45 (44%)
		KELCH repeat	423..466	CDD:276965	19/42 (45%)
		Kelch	435..480	CDD:128874	19/44 (43%)
		Kelch_1	469..514	CDD:279660	20/50 (40%)
		KELCH repeat	470..514	CDD:276965	19/49 (39%)
		Kelch_1	517..560	CDD:279660	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
klhl5	XP_002938696.2	PHA03098	174..696	CDD:222983	214/527 (41%)
		KELCH repeat	458..501	CDD:276965	19/42 (45%)
		KELCH repeat	505..549	CDD:276965	19/43 (44%)
		KELCH repeat	552..595	CDD:276965	19/42 (45%)
		KELCH repeat	599..648	CDD:276965	19/48 (40%)
		KELCH repeat	652..695	CDD:276965	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920