Protein Alignment KLHL18 and klhl28

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_017952205.1
• Gene: klhl28 / 100493680
• XenbaseID: XB-GENE-994648
• Length: 573
• Species: Xenopus tropicalis
• Alignment Length: 534
• Identity: 203/534 - (38%)
• Similarity: 299/534 - (55%)
• Gaps: 19/534 - (3%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|:..:|||:.|:|.|....||:||||:..|||.||||.|::|....::..:  :::.:||:::|
 Frog    30 LRQHHELCDIVLQVGDVKIHAHKVVLASISPYFKAMFTGNLSEKENSQVEFQ--SVDEAALQAII 92

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            .|.|:|.|.|..:.|::|:..|:.||:..|...|.:||.|:....|.:||..||::..|.:|..|
 Frog    93 EYAYTGTVFISQETVESLLPAANLLQIKLVLKECCAFLESQLDVGNCIGISRFAETYGCHELYLA 157

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            |:|||.|||..|.|:|||..|...:|.|::..|.|||..||.:|.|...|:||...:|.:...|:
 Frog   158 ANKYICQNFEDVCQTEEFFELSNSELHEIVSNDCLNVVNEETVFYALESWIKYDVQERQKYLAQL 222

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQS-FRTRQRSGEFFT 290
            |..|||||||.:||........|||..|.|:.||:||..:|.|||.|...|: .:|:.|..   .
 Frog   223 LHCVRLPLLSVKFLTRLYEANHLIRDDHTCKHLLNEALKYHFMPEHRLSHQTVLKTQPRCA---P 284

  Fly   291 GQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFG--------GF 347
            ..:.||||.|.....:.::|:|.|....|.....:...|...|:..|:.|:|..|        |.
 Frog   285 KVLCAVGGKAGLFACLESMEMYFPQDDSWIGLAPLGSPRYEFGLCTLDQKVYVVGGIATHMRQGI 349

  Fly   348 NGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNT 412
            |..:..::||.:||..|||:....|:..||.:|...|...:|..|||||.:.|.:||.|.||:..
 Frog   350 NYRKHENSVECWDPVTNKWTSIERMIECRSTLGAVVLAGEMYALGGYDGQSCLQSVEKYIPKAKE 414

  Fly   413 WKTVAQMMKYRS--AGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGV 475
            |..||.|:|.||  ||.|  |:|.:||:||: |.:..:||||||.:.|.|..::.|.::|...||
 Frog   415 WHPVAPMIKTRSCFAGAV--LDGMIYAIGGY-GPAHMNSVERYDPSRDSWEMVASMEDKRINFGV 476

  Fly   476 ATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESN 540
            :.:.|.|:|.||:.|.:.|.|:|.|||..:.|.:..||...|:.|..|.....|:.:||:.|.|.
 Frog   477 SVMLGFIFVVGGHNGVAHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVVDNYLYVVGGHSGSSY 541

  Fly   541 LSTVEVYDPETDKW 554
            |:.|:.|||.:|.|
 Frog   542 LNYVQKYDPISDTW 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	39/104 (38%)
		PHA03098	36..510	CDD:222983	185/484 (38%)
		KELCH repeat	329..372	CDD:276965	15/50 (30%)
		KELCH repeat	376..417	CDD:276965	17/40 (43%)
		KELCH repeat	423..466	CDD:276965	20/44 (45%)
		KELCH repeat	470..514	CDD:276965	17/43 (40%)
		Kelch_1	517..560	CDD:396078	15/38 (39%)
		KELCH repeat	517..560	CDD:276965	15/38 (39%)
klhl28	XP_017952205.1	PHA03098	37..555	CDD:222983	200/525 (38%)
		KELCH repeat	323..374	CDD:276965	15/50 (30%)
		KELCH repeat	378..421	CDD:276965	19/42 (45%)
		KELCH repeat	425..467	CDD:276965	20/44 (45%)
		KELCH repeat	471..515	CDD:276965	17/43 (40%)
		KELCH repeat	518..561	CDD:276965	15/38 (39%)