DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and kbtbd8

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002938415.2	Gene:	kbtbd8 / 100492015	XenbaseID:	XB-GENE-956237	Length:	633	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	152/555 - (27%)
Similarity:	251/555 - (45%)	Gaps:	107/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRM---GKLCDVTLKVE-DQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIE 88
            :.::::.|   |||.|:.::|: .:.||.||.||||..|||.:|||:.:.||..||:.:  ..||
Frog    68 ILQQLKAMYDEGKLTDIVVQVDHGKHFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRL--VGIE 130

  Fly    89 PSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSM 153
            ..:::.::||.|:.:|::...|||.|...||..|:.:::|.||.::|||..|.|.:|:.:|||..
Frog   131 AESMQLVLNYAYTSRVQLTEANVQALFTAASIFQIPSLQDQCAQYMISRLEPQNCIGVFSFADHY 195

  Fly   154 ICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDK 218
            ..::|.:.|..||.:.|..|::.:|||.|..:||:.::..|:|:|..||.::::.:.|.::.::.
Frog   196 GHQELKEKAQDYIRKKFLYVTKEQEFLHLRKDQLISILNSDDLDVEKEEHVYDSIISWYEHEQET 260

  Fly   219 RSELFPQVLA-AVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERR---GLLQSF 279
            |....|::.| .:|:||:...|:             .|...:..:|     ||..|   |.:.:.
Frog   261 REMHLPEIFAKCIRMPLMEETFV-------------EQIPPIFAQA-----MPINRVQKGKISAN 307

  Fly   280 RTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLT-KKWKMGEQMSMMRSRVGVAVL-NGKLY 342
            ...:|.|...:..|..............||...|.|| |.:|:.:....:| .||:.|. :.:||
Frog   308 CCTRRLGMTASEMIICFEAANKHSGKKQTVPCLDTLTGKVYKLCKPPGDLR-EVGILVTPDNELY 371

  Fly   343 AFGGFNGTERLSTVE--------VYDPRKNKWSQGCAMLCKRSAVGVAALDDC--IYVCGGY--- 394
            ..||:..:.....::        :||...|:|.....:|  |:.:|...:..|  :|..||.
Frog   372 IAGGYRPSNNDVCIDHKAESDFWLYDHSSNRWLPKAPLL--RARIGCKLVHCCGKLYAIGGRVYE 434

  Fly   395 -DGVTSLNTVEVYYPKSNTWKTVAQM---MKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQ 455
             ||...|.:||.|..:.|.|..|:.|   |::.||                        ||..|
Frog   435 GDGRNPLKSVECYDTRDNCWTAVSLMPVAMEFHSA------------------------VEYKD- 474

  Fly   456 AEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRV 520
                                     |||:..   |..||    ||||..|.|..:|||...|.:.
Frog   475 -------------------------KIYILQ---GEVFL----CYDPPRDYWCYLTPMTAPRVQG 507

  Fly   521 ALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWT 555
            ..|.....::.:.|..|...:.|||.||.|.::||
Frog   508 MAAVYKDSIYYVAGIRGNHRVLTVEAYDVEQNRWT 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	40/109 (37%)
		PHA03098	36..510	CDD:222983	136/497 (27%)
		BACK	143..245	CDD:285009	29/102 (28%)
		Kelch	292..339	CDD:128874	12/48 (25%)
		KELCH repeat	329..372	CDD:276965	12/51 (24%)
		Kelch	340..386	CDD:128874	11/53 (21%)
		KELCH repeat	376..417	CDD:276965	14/46 (30%)
		Kelch	387..433	CDD:128874	17/54 (31%)
		KELCH repeat	423..466	CDD:276965	5/42 (12%)
		Kelch	435..480	CDD:128874	3/44 (7%)
		Kelch_1	469..514	CDD:279660	14/44 (32%)
		KELCH repeat	470..514	CDD:276965	14/43 (33%)
		Kelch_1	517..560	CDD:279660	12/39 (31%)
		KELCH repeat	517..560	CDD:276965	12/39 (31%)
kbtbd8	XP_002938415.2	BTB_POZ_KBTBD8	60..188	CDD:349583	45/121 (37%)
		PHA03098	73..548	CDD:222983	152/550 (28%)
		BACK_KBTBD8	180..276	CDD:350558	28/95 (29%)
		KELCH repeat	363..409	CDD:276965	9/45 (20%)
		KELCH repeat	413..461	CDD:276965	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910