DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl17

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_004916201.1	Gene:	klhl17 / 100491332	XenbaseID:	XB-GENE-977875	Length:	627	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	248/575 - (43%)
Similarity:	350/575 - (60%)	Gaps:	20/575 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAM 67
            :|.||:        :|   :.::|.....:|:.|.|||:.|.|..:....|:||||:..|||:||
Frog    52 ISHNSK--------RH---YHDAFVCMNRMRQRGLLCDIVLHVGTKEIKGHKVVLASCSPYFHAM 105

  Fly    68 FTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACAS 132
            |||.|:|||...:|:.:  |:|.|||.|:.|.|:.::.:...|||.|:..||.|||:.|||||..
Frog   106 FTNEMSESRQTHVTLHD--IDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCK 168

  Fly   133 FLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELN 197
            ||:|:..|.|.||||.|||:..|..|:.:|.||:.|:|.:||::|||:.|..:|:|:|:..|.||
Frog   169 FLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLN 233

  Fly   198 VRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDE 262
            |.:||.::.|.:.|||:..|.|.:..|:::..|||||||..||...|..|.|:|...:|:|||.|
Frog   234 VPSEEEVYRAVLNWVKHDVDGRRQHVPRLMKCVRLPLLSRDFLMSSVDTELLVRHHSECKDLLIE 298

  Fly   263 AKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGG---LASTGESVSTVEIYDPLTKKWKMGEQ 324
            |..:|||||:||:|.:.|||.|..|..:..::||||   .|..|:    .|.||..|.:|.|...
Frog   299 ALKYHLMPEQRGVLSNSRTRPRRCEGASTVLFAVGGGSLFAIHGD----CEAYDTRTDRWHMVTS 359

  Fly   325 MSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIY 389
            ||..|:|||||.:..||||.||::||..|:|||.|||..|.|....:|..:||.:|||.|...:|
Frog   360 MSTRRARVGVAAIGNKLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAVLHGLLY 424

  Fly   390 VCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYD 454
            ..|||||.:.||:.|.|.|.:.||.::|.|...|....|..|:|.:||:||:|..|...:||:|:
Frog   425 AAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYE 489

  Fly   455 QAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSR 519
            ...:.|..::.||:||...|||.|.|.:||.||..|.|.|.|||.|:|:.:||:.|.|||.:||.
Frog   490 PQINTWTPIANMLSRRSSAGVAVLEGMLYVAGGNDGTSCLNSVERYNPKANTWESVAPMNIRRST 554

  Fly   520 VALAANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVIRI 574
            ..|.|..|.|:|:||.||.|:|:::|.|:|.|:||.....|......||..|:.:
Frog   555 HDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLEL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	48/105 (46%)
		PHA03098	36..510	CDD:222983	215/476 (45%)
		BACK	143..245	CDD:285009	45/101 (45%)
		Kelch	292..339	CDD:128874	20/49 (41%)
		KELCH repeat	329..372	CDD:276965	23/42 (55%)
		Kelch	340..386	CDD:128874	24/45 (53%)
		KELCH repeat	376..417	CDD:276965	19/40 (48%)
		Kelch	387..433	CDD:128874	18/45 (40%)
		KELCH repeat	423..466	CDD:276965	14/42 (33%)
		Kelch	435..480	CDD:128874	18/44 (41%)
		Kelch_1	469..514	CDD:279660	23/44 (52%)
		KELCH repeat	470..514	CDD:276965	22/43 (51%)
		Kelch_1	517..560	CDD:279660	19/42 (45%)
		KELCH repeat	517..560	CDD:276965	19/42 (45%)
klhl17	XP_004916201.1	BTB_POZ_KLHL17_actinfilin	38..176	CDD:349555	55/136 (40%)
		PHA03098	77..543	CDD:222983	212/471 (45%)
		KELCH repeat	321..360	CDD:276965	13/42 (31%)
		KELCH repeat	364..407	CDD:276965	23/42 (55%)
		KELCH repeat	411..454	CDD:276965	20/42 (48%)
		KELCH repeat	458..502	CDD:276965	14/43 (33%)
		KELCH repeat	505..549	CDD:276965	22/43 (51%)
		KELCH repeat	552..597	CDD:276965	20/44 (45%)
		Kelch	564..608	CDD:128874	18/43 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010