DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and kbtbd3

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002934972.1	Gene:	kbtbd3 / 100490420	XenbaseID:	XB-GENE-6044137	Length:	607	Species:	Xenopus tropicalis

Alignment Length:	581	Identity:	152/581 - (26%)
Similarity:	242/581 - (41%)	Gaps:	84/581 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSAL 92
            :.:..|......|..:.|:||....||.||||:..:|.|||..||.|.....:|:  |.:..:|:
Frog    37 ILQNFRDQKAFFDFNIIVKDQLMPCHRCVLAASSDFFRAMFEVNMKERDGGSVTI--SNLSSNAV 99

  Fly    93 ESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQ 157
            .:.::|.|:|:..|.::||..|...:||||:..:..||:.|||.....:|.|.:.:.::|....:
Frog   100 AAFLDYAYTGKAEITDENVDMLFQMSSFLQVPLLSKACSDFLIKIIDTNNCLQLLSISESYGSTR 164

  Fly   158 LIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSEL 222
            |.|.|.::..|:|:.::||.:||.|:...|.:.:..|.|||..||....|.:.|.|::.|||...
Frog   165 LFDHALEFSLQHFSLLTQSTDFLELNIGVLEKCLEDDLLNVPEEESALVAVIAWTKHSLDKRERF 229

  Fly   223 FPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGE 287
            ||::|..:||..||...|.:.:..|:.:..|..|...::.|  ...:....||....|.......
Frog   230 FPRLLRTIRLHQLSQSTLQNVLISEDQLLKSTDCLSTINSA--IKRVEAAGGLFPDARLSTTEKY 292

  Fly   288 FFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNG--------KLYAF 344
            .|..:....||...|       ..|:..|.||       :....:.:..|.|        |::..
Frog   293 IFVHKTAEDGGTQCT-------FCYNLKTDKW-------LELPHIQLTDLPGSSLSSYGEKIFIT 343

  Fly   345 GGFNG----TERLSTVEVYD----------PRKNKWSQGCAMLCKRSA-VGVAALDDCIYVCGG- 393
            ||..|    ..||...|.|.          |..|..|...||...|:. ..|.||:. ::|.||
Frog   344 GGCKGHCCRGVRLHIAEPYHDATDQTWCYCPASNNSSLVPAMKKPRTMHTSVMALNQ-LFVIGGK 407

  Fly   394 -----YDGVTSLNTVEVYYPKSNTWKTVAQMMK---YRSAGGVTQLNGYVYALGGHDGLSIFDSV 450
                 |  :.||..||.|.|.:..||:|:.:.:   |..|.....:   :|.||     |..:..
Frog   408 TKGAHY--IKSLLDVESYNPLAKEWKSVSPLPRGIYYPEASACKNV---IYVLG-----SEVEIT 462

  Fly   451 ERYDQAEDVWVKMSPMLNRRCRLGV-------ATL------NGKIYVCGGYCGNSFLRSVECYD- 501
            :.::.:.|.:.|.:...|:.|.|..       |||      |..:|:|.       |.:.:.|.
Frog   463 DAFNPSLDCFFKYNAETNQWCELVAEFGQFFHATLIKAVPVNNTLYICD-------LSTYKVYSF 520

  Fly   502 -PQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG-YDGESNLSTVEVYDPETDKWTFMPPM 560
             |:|..||......|............|::.:|| |..:.....|:||.....:|..:.||
Frog   521 CPETCVWKGEGSFECAGFNAGAVGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPM 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	35/105 (33%)
		PHA03098	36..510	CDD:222983	140/520 (27%)
		BACK	143..245	CDD:285009	33/101 (33%)
		Kelch	292..339	CDD:128874	8/46 (17%)
		KELCH repeat	329..372	CDD:276965	13/64 (20%)
		Kelch	340..386	CDD:128874	17/60 (28%)
		KELCH repeat	376..417	CDD:276965	16/47 (34%)
		Kelch	387..433	CDD:128874	15/54 (28%)
		KELCH repeat	423..466	CDD:276965	7/42 (17%)
		Kelch	435..480	CDD:128874	12/57 (21%)
		Kelch_1	469..514	CDD:279660	14/59 (24%)
		KELCH repeat	470..514	CDD:276965	14/58 (24%)
		Kelch_1	517..560	CDD:279660	8/43 (19%)
		KELCH repeat	517..560	CDD:276965	8/43 (19%)
kbtbd3	XP_002934972.1	BTB_POZ_KBTBD3_BKLHD3	24..153	CDD:349580	39/117 (33%)
		PHA03098	62..582	CDD:222983	147/556 (26%)
		KELCH repeat	330..385	CDD:276965	12/54 (22%)
		KELCH repeat	389..437	CDD:276965	17/50 (34%)
		KELCH repeat	440..485	CDD:276965	10/52 (19%)
		KELCH repeat	537..582	CDD:276965	10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910