Protein Alignment KLHL18 and kbtbd12

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_002933128.2
• Gene: kbtbd12 / 100489900
• XenbaseID: XB-GENE-1010972
• Length: 613
• Species: Xenopus tropicalis
• Alignment Length: 579
• Identity: 160/579 - (27%)
• Similarity: 263/579 - (45%)
• Gaps: 79/579 - (13%)

  Fly    32 IRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLI 96
            :|.:.:|.|..|..|.|.|..||||||:..|||.||||..:.|....|:.:.:  |...::..::
 Frog    18 MRGVAELTDTVLVAEGQRFPCHRVVLASFSPYFRAMFTCGLVECNQNEVQLHD--IPAQSVSIIL 80

  Fly    97 NYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDA 161
            :|:|:.::.|.|..||.|...|.|:|:.::...|.::::....|.|.:|:..||..:...:|.:.
 Frog    81 DYMYTSELTISNLTVQVLATAAYFMQMDDIFTLCQNYMLDHMDPSNCVGVYYFAKHICGEELEER 145

  Fly   162 ADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQV 226
            ..||:.|:|.:|...||.|.::.:||:.:::.|:|||..||.|.:..::||.:.:..|||....:
 Frog   146 CKKYLYQHFTEVGLHEEILEIEFDQLMGMIKSDDLNVSREESILDLVLRWVNHDKTARSEYLVDL 210

  Fly   227 LAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRT--RQRSGEFF 289
            |..|||.|:||.||.:...|..::..:.||.|:::||.:        .:.:|.:|  ..|.|...
 Frog   211 LKQVRLLLVSPSFLREARKRNTVLLCNSQCYDIVEEALE--------TIEKSSQTSLSLRYGMET 267

  Fly   290 TGQIYAVG----GLASTGESVSTVEI-YDPLTKKW------KMGEQMSMMRSRVGVAVLNGKLYA 343
            |..:..:|    |:.|...|...... :.|.|.|.      |.||.:..:.:  ||...|..:..
 Frog   268 TNILLCIGNNAMGIRSRYGSFGDASFCFAPATGKCCFIPSPKQGEVLGSVLA--GVVTENNDIIL 330

  Fly   344 FGGFNGT----ERLSTVEV--YDPRKNKWSQGCAMLCK---RSAVGVAALDDCIYVCGG---YDG 396
            .|..:..    ::...||:  |   .|:.|.....||.   |....:|:|.:.:|:.||   |..
 Frog   331 AGEASSVRLARQKTKMVELCRY---HNRGSYCWERLCSAEYRELYALASLHNDLYLIGGQMKYKN 392

  Fly   397 ---VTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG-----------HDGLSIF 447
               ||  |.||.:..:..:|:.|..:....:......:|..::.:||           .|.||
 Frog   393 QYIVT--NCVEKFSMEKESWRNVTPLPIPLACHAAVTVNNKLFVMGGWTPQTDRPDDEPDRLS-- 453

  Fly   448 DSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIYVCGGY------------CGNSFLRSVECY 500
            :.:.:||.|.|.|..|:.|...:.|...|.:|.:|||.||.            |    |.:||.|
 Frog   454 NRLLQYDPALDKWTIMASMKYSKYRFSAAVVNNEIYVLGGIGCIGPDKGQVRKC----LDAVEIY 514

  Fly   501 DPQTDTWK----LVTPMNCKRSRVALA-ANMGKLWAIGGYDGESNLSTVEVYDPETDKW 554
            :|..|.|:    :..|:...||..:.| |..|||:..||:.|......:.....|.|.|
 Frog   515 NPDGDFWRDGPAMPYPLLSLRSNASSAGAVEGKLYVCGGFQGADRYEVITKEILELDPW 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	34/104 (33%)
		PHA03098	36..510	CDD:222983	145/528 (27%)
		KELCH repeat	329..372	CDD:276965	9/48 (19%)
		KELCH repeat	376..417	CDD:276965	13/46 (28%)
		KELCH repeat	423..466	CDD:276965	12/53 (23%)
		KELCH repeat	470..514	CDD:276965	17/59 (29%)
		Kelch_1	517..560	CDD:396078	13/39 (33%)
		KELCH repeat	517..560	CDD:276965	13/39 (33%)
kbtbd12	XP_002933128.2	BTB_POZ_KBTBD12	4..130	CDD:349585	36/113 (32%)
		PHA03098	39..593	CDD:222983	153/558 (27%)
		BACK_KBTBD12	122..221	CDD:350560	33/98 (34%)
		KELCH repeat	369..416	CDD:276965	14/48 (29%)
		KELCH repeat	420..473	CDD:276965	12/54 (22%)
		KELCH repeat	476..529	CDD:276965	16/56 (29%)
		KELCH repeat	535..587	CDD:276965	13/39 (33%)