DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl6

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002933397.2	Gene:	klhl6 / 100486936	XenbaseID:	XB-GENE-983196	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	634	Identity:	184/634 - (29%)
Similarity:	278/634 - (43%)	Gaps:	136/634 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLSDNSQVEDQYFVYKHDKLFGESFPL-----FKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATI 61
            :|.:||..:::       |.....|.|     .:.:|....|.||.|.|.|:.|..|||||||..
Frog    26 ELIENSSGDNR-------KFDDTGFTLALQSGLENLRLENSLTDVVLCVGDKVFPCHRVVLAAAS 83

  Fly    62 PYFYAMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNV 126
            .||.|||.|::.|...::|.::  .:||..::.:::|.|:.:|.|...|||.::..||..|...:
Frog    84 NYFRAMFCNDLKEKYEEKIIIQ--GVEPETMQIILDYTYTSKVVITKLNVQKILEAASLFQFLRM 146

  Fly   127 RDACASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELM 191
            .|||:|||....||.|.:||...||:.....|......||.|||::|...|:|..|..|.|..::
Frog   147 VDACSSFLTEALHPENCVGILRLADAHSLESLKVQVQNYIIQNFSQVLNQEDFFELPFEILFHML 211

  Fly   192 RRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQC 256
            :.|:|.|..|..:||..:.||:|.:.:|.||.|:::..||||||.|.:|...|...||||   ||
Frog   212 KSDDLYVTEEAQVFETVINWVEYKKSERLELLPKIMECVRLPLLDPWYLVGNVEANELIR---QC 273

  Fly   257 RD---LLDEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTK- 317
            .|   |:.||:.:::....   :.|.||:.|..||.:.....:||.....:.|:.|...|||.:
Frog   274 PDVFPLMQEARIYYMAGNE---VISERTKPRIHEFQSEVFMIIGGCTKDEKFVTEVTCLDPLRRS 335

  Fly   318 -----------------------------------------------------KWKMGEQMSMMR 329
                                                                 ||...|.:::.|
Frog   336 RLEVAKLPVSDHENESENKKWVEFACITFKNEVYISGGKDTQQEVWKYNSSINKWIQIEYLNVGR 400

  Fly   330 SRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGY 394
            .|..:|.|.||:||.|||:|::|:.:||||||..|.|::...:|...|:...|.....:||.|
Frog   401 WRHKMAALCGKVYAIGGFDGSQRIYSVEVYDPFHNGWTEVAPLLISASSFAAACHQKKLYVIG-- 463

  Fly   395 DGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDV 459
                                                        ||.:|....|..:.||...:.
Frog   464 --------------------------------------------GGPNGKLATDKTQCYDPETNK 484

  Fly   460 WVKMSPM-LNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALA 523
            |...||| :..:| :...:.|..|||.||     .::::..|.|..|||.|||....:|:...:|
Frog   485 WCLKSPMPVEAKC-INAVSFNDHIYVVGG-----AMKALYSYSPLEDTWCLVTKFTHERASCGIA 543

  Fly   524 ANMGKLWAIGGYDGESN--LSTVEVYDPETDKWT---FMPPMCAHSGGV 567
            |...|::..||.| |.|  ::||..::.||:|.|   .:|...:|...|
Frog   544 ACCNKIFITGGRD-EKNEVIATVLCWNVETEKLTEECVLPRGVSHHSSV 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	40/105 (38%)
		PHA03098	36..510	CDD:222983	156/531 (29%)
		BACK	143..245	CDD:285009	37/101 (37%)
		Kelch	292..339	CDD:128874	14/100 (14%)
		KELCH repeat	329..372	CDD:276965	21/42 (50%)
		Kelch	340..386	CDD:128874	19/45 (42%)
		KELCH repeat	376..417	CDD:276965	5/40 (13%)
		Kelch	387..433	CDD:128874	3/45 (7%)
		KELCH repeat	423..466	CDD:276965	8/42 (19%)
		Kelch	435..480	CDD:128874	11/45 (24%)
		Kelch_1	469..514	CDD:279660	15/44 (34%)
		KELCH repeat	470..514	CDD:276965	15/43 (35%)
		Kelch_1	517..560	CDD:279660	16/47 (34%)
		KELCH repeat	517..560	CDD:276965	16/47 (34%)
klhl6	XP_002933397.2	BTB_POZ_KLHL6	37..165	CDD:349545	47/129 (36%)
		PHA03098	63..554	CDD:222983	161/550 (29%)
		BACK_KLHL6	158..265	CDD:350521	40/106 (38%)
		KELCH repeat	359..396	CDD:276965	3/36 (8%)
		KELCH repeat	400..444	CDD:276965	21/43 (49%)
		KELCH repeat	447..493	CDD:276965	15/91 (16%)
		KELCH repeat	495..531	CDD:276965	13/41 (32%)
		KELCH repeat	537..581	CDD:276965	15/44 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910