Protein Alignment KLHL18 and klhl10

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_012810304.1
• Gene: klhl10 / 100486163
• XenbaseID: XB-GENE-6047527
• Length: 609
• Species: Xenopus tropicalis
• Alignment Length: 546
• Identity: 162/546 - (29%)
• Similarity: 265/546 - (48%)
• Gaps: 55/546 - (10%)

  Fly    30 KEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALES 94
            :.:|:.|:||||.|.....|||||:::|.....||..:||.:.::.......:  ..:.|..|..
 Frog    26 ERLRQEGRLCDVELSAGGATFSAHKIILCGCSSYFRQLFTGSWSDPMRSRYWI--PGLSPEMLRL 88

  Fly    95 LINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLI 159
            ::::.|:|.|.:...|.:.|.|.|....:..|..||.:|:.|:..|.|.||:..|:....|.:|.
 Frog    89 ILDFAYTGAVGVTADNAEELFVAADQFSVMGVARACVAFMGSQLCPQNCLGMWRFSAYYPCPELR 153

  Fly   160 DAADKYIDQNFAKV-SQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELF 223
            ..|..::.::|.:| ::|.||.....::|.|::..|:|||:.||.:|:..::|:|...:.|.:..
 Frog   154 QRAHSFLLRHFQQVGAESPEFRTAAPQELAEIIGSDQLNVQQEEALFQLIVQWIKMEPETRRDAI 218

  Fly   224 PQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEF 288
            ..:|..|||.|::..:|.:.|...|.:..|..|:.|:..|               .|.|.
 Frog   219 SNLLPKVRLALMNTDYLLNTVQDHEYVAHSEPCQSLVTHA---------------LRLRY----- 263

  Fly   289 FTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERL 353
                     ||...|.  |..:.::|||            |.|:...:    |:|.||::|....
 Frog   264 ---------GLDMNGP--SAFDFHNPLT------------RPRLPYNI----LFAIGGWSGRSPT 301

  Fly   354 STVEVYDPRKNKWS--QGCAMLCKRSAVGVAALDDCIYVCGGYDGVTSLNTVEVYYPKSNTWKTV 416
            |.:||||.|.::|:  :|.:   .|:..|...|.:.|||.||:|.....|||..:......|:.|
 Frog   302 SAIEVYDERADRWAELEGHS---PRAYHGAVFLGNFIYVLGGFDSADYFNTVRRFSLAQRRWEEV 363

  Fly   417 AQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAEDVWVKMSPMLNRRCRLGVATLNGK 481
            :.|...|....|..|:||:||:||.||....::.|||....:.|..:|.|..:|.......|:||
 Frog   364 SPMHTRRCYLSVAVLHGYIYAMGGFDGYVRLNTAERYQPHTNQWSLISTMHEQRSDASATVLHGK 428

  Fly   482 IYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGGYDGESNLSTVEV 546
            :|:|||:.||..|.:.|.|.|.|:.|.|:.||..:||.|.:...:.:::|:||:||...|::.|.
 Frog   429 VYICGGFNGNECLPTAEVYSPDTNQWSLIAPMGSRRSGVGVVTFLEQIFAVGGFDGTERLNSAEC 493

  Fly   547 YDPETDKWTFMPPMCAHSGGVGAGVI 572
            |.|.|:.|:..|||.......|..|:
 Frog   494 YAPNTNTWSQAPPMFNTRSNFGIEVL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	30/106 (28%)
		PHA03098	36..510	CDD:222983	139/476 (29%)
		KELCH repeat	329..372	CDD:276965	15/44 (34%)
		KELCH repeat	376..417	CDD:276965	13/40 (33%)
		KELCH repeat	423..466	CDD:276965	16/42 (38%)
		KELCH repeat	470..514	CDD:276965	18/43 (42%)
		Kelch_1	517..560	CDD:396078	15/42 (36%)
		KELCH repeat	517..560	CDD:276965	15/42 (36%)
klhl10	XP_012810304.1	PHA03098	32..566	CDD:222983	161/540 (30%)
		KELCH repeat	323..366	CDD:276965	14/42 (33%)
		KELCH repeat	370..413	CDD:276965	16/42 (38%)
		KELCH repeat	417..461	CDD:276965	18/43 (42%)
		KELCH repeat	464..507	CDD:276965	15/42 (36%)
		KELCH repeat	511..554	CDD:276965	2/9 (22%)