DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and kbtbd2

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002937037.1	Gene:	kbtbd2 / 100380094	XenbaseID:	XB-GENE-1012666	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	159/595 - (26%)
Similarity:	244/595 - (41%)	Gaps:	128/595 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLSDNSQVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFY 65
            |...|.:|:..:|.|...::|     .||.|   ...|.|:.|.||...|..|::|||....||.
Frog     1 MSTQDETQINTEYAVSLLEQL-----KLFYE---QQLLTDIVLIVEGTEFPCHKMVLATCSSYFR 57

  Fly    66 AMFTNNMAESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDAC 130
            |||.:.::||:...:.::.  ::.::|:.:|.|.|:|.:.|:...|:.|...|.|||:.:|...|
Frog    58 AMFMSGLSESKQTHVHLRN--VDAASLQIIITYAYTGNLAINESTVEQLYETACFLQVDDVLQLC 120

  Fly   131 ASFLISRFHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDE 195
            ..:||.:.:..|.:.:.:|||...|.:|..:|.:.::..|..|...|.|:.|..|.|:||:..|.
Frog   121 REYLIKKINAKNCVRLLSFADLFSCEELKQSAKRMVEHKFTTVYHQEAFMQLSSELLIELVSSDN 185

  Fly   196 LNVRTEEVIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLL 260
            |||..||.:.||.|.|:.|....||:....||:.:|:..||           |:|
Frog   186 LNVEKEETVREAAMSWLDYNTVSRSQYLSTVLSHLRIDALS-----------EVI---------- 229

  Fly   261 DEAKDFHLMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLASTGESVSTVEIYDPLTKKWKMGEQM 325
                                  ||  |:|.       ||....:||....:|..:.:.:|
Frog   230 ----------------------QR--EWFQ-------GLPPNDKSVVVQGLYKSMPRFFK----- 258

  Fly   326 SMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKN---KWSQGCAMLCKRSAVG-VAALDD 386
                .|:|:......:............||| .|.|:..   |.|...|.|.|   || |...|:
Frog   259 ----PRLGMTKEEMIIIIEAASENPSYCSTV-CYSPQAEKVYKLSNPPAELHK---VGTVVTPDN 315

  Fly   387 CIYVCGGYDGV--------------TSLNTVEVYY---PKSNTWKTVAQMMKYRSAGGVTQLNGY 434
            .||:.||...|              .:..||..:|   .:.|||.....|:..|:...:...:||
Frog   316 DIYIAGGQVPVKTTKSNHSKPSKLQAAFRTVNCFYWFDAQQNTWIPKTPMLSVRTKPSLVWCDGY 380

  Fly   435 VYALGGHDGLSIFD--SVERYDQAEDVWVKMSPMLNRRC--RLGVA-TLNGKIYVCGGYCGNSFL 494
            :||:||.:.....:  :|||||...|.|..:||:   .|  :..|| .::..|||..       .
Frog   381 IYAIGGDNAGGELNRRTVERYDCERDEWTMVSPL---PCAWQWNVAVVVHDCIYVMA-------Y 435

  Fly   495 RSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG---------------YDGESNLSTV 544
            ....||.|:|..|..:......|...:.||...|::.:||               .||.|  .||
Frog   436 NMTYCYVPRTGMWVEMAMRQTSRCFASAAAFEDKIFYLGGVHIGNSSGIRLPSNTVDGSS--VTV 498

  Fly   545 EVYDPETDKW 554
            ||||...::|
Frog   499 EVYDVNKNEW 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	33/105 (31%)
		PHA03098	36..510	CDD:222983	134/499 (27%)
		BACK	143..245	CDD:285009	33/101 (33%)
		Kelch	292..339	CDD:128874	8/46 (17%)
		KELCH repeat	329..372	CDD:276965	9/45 (20%)
		Kelch	340..386	CDD:128874	13/49 (27%)
		KELCH repeat	376..417	CDD:276965	15/58 (26%)
		Kelch	387..433	CDD:128874	13/62 (21%)
		KELCH repeat	423..466	CDD:276965	15/44 (34%)
		Kelch	435..480	CDD:128874	16/49 (33%)
		Kelch_1	469..514	CDD:279660	11/47 (23%)
		KELCH repeat	470..514	CDD:276965	11/46 (24%)
		Kelch_1	517..560	CDD:279660	16/53 (30%)
		KELCH repeat	517..560	CDD:276965	16/53 (30%)
kbtbd2	XP_002937037.1	BTB_POZ_KBTBD2_BKLHD1	5..137	CDD:349579	42/141 (30%)
		PHA03098	23..510	CDD:222983	153/568 (27%)
		BACK_KBTBD2	128..223	CDD:350554	32/94 (34%)
		KELCH repeat	309..365	CDD:276965	13/55 (24%)
		KELCH repeat	369..415	CDD:276965	16/48 (33%)
		KELCH repeat	418..452	CDD:276965	10/40 (25%)
		KELCH repeat	458..515	CDD:276965	16/53 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910