DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and ipp

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_012816160.1	Gene:	ipp / 100327249	XenbaseID:	XB-GENE-491275	Length:	584	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	184/569 - (32%)
Similarity:	285/569 - (50%)	Gaps:	49/569 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KHDKLFGESFPLFKEIRRMG---KLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIK 78
            ||.:|      :..::.||.   :.|||.:::.|..|..|::||||:.|||.|:....|.||..:
Frog    18 KHAQL------ILAQMNRMRHQLEFCDVQIQIGDVKFGVHKLVLAASSPYFAALLAGGMKESLTE 76

  Fly    79 EITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNV 143
            .:.::  .:.|::.:.:::::|:|.|:|...||::||..|..||||:|.:.|..||.....|.|.
Frog    77 VVQIQ--GLNPNSFQLILDFIYTGSVKISTDNVEDLMTAADMLQLSHVVELCCDFLKEHTEPANC 139

  Fly   144 LGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEAC 208
            :|...||:.:.|:.|::..:.||..:|.:|...:||..|..:||:::::.:||::..|..:|.|.
Frog   140 IGFFQFAEHLSCQPLLEYTESYIHTHFTEVQIGDEFPTLTKDQLVQILQSEELSIEDEYQVFSAA 204

  Fly   209 MKWVKYAEDKRSELFPQVLAAVRLPLLSPQFL-------AD---RVAREELIRSSHQCRDLLDEA 263
            |.|::.....|.....:||..||..||.|:.|       ||   |||.:.|:|  ..| :|....
Frog   205 MIWIQKDIVTRKRHVIEVLEPVRFSLLPPKRLHKAIEDVADFSLRVALQTLLR--EYC-ELSHSP 266

  Fly   264 KDFHLMPERRGLLQSFRTR-QRSGEFFTGQIYAVGGLA-------STGESVSTVEIYDPLTKKWK 320
            ||..|.    ..||:.|.| :|....|   :||:||..       |...::|.||.:|..::.|.
Frog   267 KDKKLC----NFLQTSRVRPRRKARKF---LYAIGGYTRLLGGRWSDSRALSCVERFDTFSQYWS 324

  Fly   321 MGEQMSMMRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALD 385
            ....:...||.:.||||.|::|..||...:.....||.|||...:|:...:|...|..:||.|..
Frog   325 TVSSLHQARSGMSVAVLEGRIYVIGGEKDSMIFDCVECYDPVSKQWAAVSSMNQPRCGLGVCACH 389

  Fly   386 DCIYVCGGYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGG--HDGLSIFD 448
            ..||..||:.|....|::|.:.|:.|.|:.|..|...|......:..|.:|.:||  |:|..: .
Frog   390 GAIYALGGWVGSEIGNSIERFSPEENAWQVVGSMAVPRYNFACCERQGMIYVVGGISHEGTEL-R 453

  Fly   449 SVERYDQAEDVWVKMSPMLNRRCRLGVATLNGKIY-VCGGYCGNSFLRSVECYDPQTDTWKLVTP 512
            |.|.||.....|:.:.||..||..||||.||..:| |.||......|.:||.:..:.:.|..|.|
Frog   454 SAEVYDPITRRWMSLPPMGTRRAYLGVACLNDCLYAVGGGDDSQDALNTVEKFSFEEEQWVEVAP 518

  Fly   513 MNCKRSRVALAANMGKLWAIGGYDGESNLS------TVEVYDPETDKWT 555
            |...|..|::.:..|.|:|.||...:.|.:      |||||:|.||.||
Frog   519 MKIPRCGVSVVSVNGLLYAAGGRSIKQNFTAPVTTDTVEVYNPHTDSWT 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	36/108 (33%)
		PHA03098	36..510	CDD:222983	158/497 (32%)
		BACK	143..245	CDD:285009	33/111 (30%)
		Kelch	292..339	CDD:128874	16/53 (30%)
		KELCH repeat	329..372	CDD:276965	16/42 (38%)
		Kelch	340..386	CDD:128874	14/45 (31%)
		KELCH repeat	376..417	CDD:276965	14/40 (35%)
		Kelch	387..433	CDD:128874	13/45 (29%)
		KELCH repeat	423..466	CDD:276965	12/44 (27%)
		Kelch	435..480	CDD:128874	19/46 (41%)
		Kelch_1	469..514	CDD:279660	18/45 (40%)
		KELCH repeat	470..514	CDD:276965	17/44 (39%)
		Kelch_1	517..560	CDD:279660	18/45 (40%)
		KELCH repeat	517..560	CDD:276965	18/45 (40%)
ipp	XP_012816160.1	BTB_POZ_KLHL27_IPP	17..141	CDD:349565	42/130 (32%)
		PHA03098	30..567	CDD:222983	178/549 (32%)
		KELCH repeat	333..376	CDD:276965	16/42 (38%)
		KELCH repeat	380..424	CDD:276965	15/43 (35%)
		KELCH repeat	427..473	CDD:276965	14/46 (30%)
		KELCH repeat	475..520	CDD:276965	17/44 (39%)
		KELCH repeat	523..574	CDD:276965	18/45 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010