DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLHL18 and klhl20

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001135481.1	Gene:	klhl20 / 100216018	XenbaseID:	XB-GENE-960635	Length:	234	Species:	Xenopus tropicalis

Alignment Length:	193	Identity:	72/193 - (37%)
Similarity:	109/193 - (56%)	Gaps:	10/193 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEI 80
            |..||...::..:...:|:..:||||.|.|..:...||||:|:|..|||.||||..:||||..|:
Frog    45 YVSDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109

  Fly    81 TMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLG 145
            .:::  |:..|:|.||::.|:.|:.::..|||.|:..|..|||:.:::||..||..:..|.|.||
Frog   110 VIRD--IDERAMELLIDFSYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 172

  Fly   146 IRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEEVIFEAC 208
            ||.|||:..||:|:..|||:...||.:|..|..|..|:...:|.        ..|:..:..||
Frog   173 IRAFADTHSCRELLRIADKFTQHNFQEVRDSVLFRKLNSAYVLV--------ANTQYGVMTAC 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	43/105 (41%)
		PHA03098	36..510	CDD:222983	68/173 (39%)
		BACK	143..245	CDD:285009	23/66 (35%)
		Kelch	292..339	CDD:128874
		KELCH repeat	329..372	CDD:276965
		Kelch	340..386	CDD:128874
		KELCH repeat	376..417	CDD:276965
		Kelch	387..433	CDD:128874
		KELCH repeat	423..466	CDD:276965
		Kelch	435..480	CDD:128874
		Kelch_1	469..514	CDD:279660
		KELCH repeat	470..514	CDD:276965
		Kelch_1	517..560	CDD:279660
		KELCH repeat	517..560	CDD:276965
klhl20	NP_001135481.1	BTB	59..162	CDD:279045	43/104 (41%)
		BTB	69..165	CDD:197585	41/97 (42%)
		BACK_Kelch	165..>203	CDD:269808	18/37 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010