DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KLHL18 and klhl18

DIOPT Version :9

Sequence 1:	NP_001262494.1	Gene:	KLHL18 / 41458	FlyBaseID:	FBgn0037978	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001123404.1	Gene:	klhl18 / 100170176	XenbaseID:	XB-GENE-5759414	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	306/570 - (53%)
Similarity:	412/570 - (72%)	Gaps:	8/570 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QVEDQYFVYKHDKLFGESFPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNM 72
            ::||...|...| |....:.:.:||||.||||||||:|.:..|||||:||||:||||:|||||:|
Frog     7 ELEDLVHVTVGD-LPSRGYGVMEEIRRQGKLCDVTLRVGEHKFSAHRIVLAASIPYFHAMFTNDM 70

  Fly    73 AESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISR 137
            .|.:..||.|:  .::.||||:|||:.|:|.:.||.||||:|::|||||||.|::|||.:||..|
Frog    71 VECKQDEIVMQ--GMDASALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACCTFLKER 133

  Fly   138 FHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEE 202
            .||.|.||:|.||::|:|..|.||::::|.::|.:||.|||||||..|::|||:.||||||:.||
Frog   134 LHPKNCLGVRQFAETMMCAVLHDASNRFIHEHFVEVSMSEEFLALAFEEVLELVSRDELNVKAEE 198

  Fly   203 VIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFH 267
            .:|||.:.||:|..:||....|::|:.:||||..||||.|||.:::|:|..|:||||:|||||:|
Frog   199 QVFEAALAWVRYDREKREVFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHKCRDLVDEAKDYH 263

  Fly   268 LMPERRGLLQSFRTRQRSGEFFTGQIYAVGGLAS-----TGESVSTVEIYDPLTKKWKMGEQMSM 327
            ||||||..|.:|:||.|......|.|||||||.|     .|:|::.||::||:..:|:..:.|:.
Frog   264 LMPERRPHLLAFKTRPRCCTSIAGLIYAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCQPMTT 328

  Fly   328 MRSRVGVAVLNGKLYAFGGFNGTERLSTVEVYDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCG 392
            .||||||||:||.|||.||::|..||||||||:|..:.|::..:|..||||:|...||..|||||
Frog   329 ARSRVGVAVVNGLLYAIGGYDGQSRLSTVEVYNPDTDTWTKVGSMNSKRSAMGTVVLDGQIYVCG 393

  Fly   393 GYDGVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDSVERYDQAE 457
            ||||..|||:||.|.|:::.|..|..|...|||.|||...|.:|..||||||.||::||.|:...
Frog   394 GYDGNCSLNSVEAYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFNTVEYYNHHT 458

  Fly   458 DVWVKMSPMLNRRCRLGVATLNGKIYVCGGYCGNSFLRSVECYDPQTDTWKLVTPMNCKRSRVAL 522
            ..|..::.|:|:|||.|.|:|..|:|:||||.|::||...|.|:...|.|.|:||||.:||||:|
Frog   459 ATWHPVASMMNKRCRHGAASLGSKMYICGGYEGSAFLSVAEVYNSMADQWYLITPMNTRRSRVSL 523

  Fly   523 AANMGKLWAIGGYDGESNLSTVEVYDPETDKWTFMPPMCAHSGGVGAGVI 572
            .||.|:|:|:|||||:|||::||:|||||::||||.||..|.||||.|.|
Frog   524 VANCGRLYAVGGYDGQSNLNSVEMYDPETNRWTFMAPMVCHEGGVGVGCI 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_001262494.1	BTB	29..135	CDD:279045	64/105 (61%)
		PHA03098	36..510	CDD:222983	254/478 (53%)
		BACK	143..245	CDD:285009	53/101 (52%)
		Kelch	292..339	CDD:128874	24/51 (47%)
		KELCH repeat	329..372	CDD:276965	26/42 (62%)
		Kelch	340..386	CDD:128874	23/45 (51%)
		KELCH repeat	376..417	CDD:276965	23/40 (58%)
		Kelch	387..433	CDD:128874	25/45 (56%)
		KELCH repeat	423..466	CDD:276965	20/42 (48%)
		Kelch	435..480	CDD:128874	21/44 (48%)
		Kelch_1	469..514	CDD:279660	22/44 (50%)
		KELCH repeat	470..514	CDD:276965	22/43 (51%)
		Kelch_1	517..560	CDD:279660	29/42 (69%)
		KELCH repeat	517..560	CDD:276965	29/42 (69%)
klhl18	NP_001123404.1	BTB_POZ_KLHL18	18..133	CDD:349556	67/117 (57%)
		PHA03098	33..556	CDD:222983	284/524 (54%)
		BACK_KLHL18	134..240	CDD:350532	55/105 (52%)
		KELCH repeat	281..326	CDD:276965	16/44 (36%)
		KELCH repeat	330..373	CDD:276965	26/42 (62%)
		KELCH repeat	377..421	CDD:276965	24/43 (56%)
		KELCH repeat	424..468	CDD:276965	20/43 (47%)
		KELCH repeat	471..515	CDD:276965	22/43 (51%)
		KELCH repeat	518..561	CDD:276965	29/42 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4921
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14805
Inparanoid	1	1.050	613	1.000	Inparanoid score	I889
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		oto102316
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060