Protein Alignment KLHL18 and klhl32

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001076491.1
• Gene: klhl32 / 100009653
• ZFINID: ZDB-GENE-070209-47
• Length: 620
• Species: Danio rerio
• Alignment Length: 569
• Identity: 162/569 - (28%)
• Similarity: 268/569 - (47%)
• Gaps: 46/569 - (8%)

  Fly    33 RRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNMAESRIKEITMKESAIEPSALESLIN 97
            |:.|.||||||...:|.|.||:.||||...||.|||:..|.||...|:|::  .:....|:..::
Zfish    36 RKDGLLCDVTLVAGEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVTLQ--GVTSVGLKHALD 98

  Fly    98 YVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISRFHPHNVLGIRTFADSMICRQLIDAA 162
            :.|:||:.::...:|:::...|.|||..:...|:.:|....:..|.|.:...||......|.:|.
Zfish    99 FAYTGQIMLEPGVIQDVLSAGSHLQLLELLSLCSHYLTQELNSFNYLDLYRLADLFHLPALEEAV 163

  Fly   163 DKYIDQNFAKV--SQSEEFLALDCEQLLELMRRDELNVRTEEVIFEACMKWVKYAEDKRSELFPQ 225
            ..::..:.:::  |:.||.|.|....|.|:::.|.|...:||.|::..::|:::  |.|.:...:
Zfish   164 VGFVVDHLSELQRSRQEEVLLLPYRLLREVLKSDRLTSLSEEEIWQLLVRWLEH--DCRYQYMEE 226

  Fly   226 VLAAVRLPLLSPQFLADRVAR-EELIRSSHQCRDLLDEAKDFHLMPERRGLLQSFRTRQRSGEFF 289
            :|..||..|:....| .|||. ..|:.||....||::||.|:|.....:.|.|:.||..|   |.
Zfish   227 LLQHVRYGLMEVPAL-HRVANSHSLLNSSSTVADLVEEALDYHRSVFAQPLRQTARTTPR---FQ 287

  Fly   290 TGQIYAVGGLASTGESVSTVEIYDPLTKK---------WKMGEQMSMMRSRVGVAVLNGKLYAFG 345
            :..:|.|||.......|..:..::|..::         |.....|...||...|||:...|:..|
Zfish   288 SLTLYIVGGRKREVSRVRELRFFNPAAQEHMRVTGGSNWSELAPMPAGRSHHCVAVMGSFLFVAG 352

  Fly   346 G--FNGTERLSTVEV---YDPRKNKWSQGCAMLCKRSAVGVAALDDCIYVCGGYDGVTS-LNTVE 404
            |  .:.|.|...|..   ||||.|:|::...|...|....:.||...:|..||.:.:.. |.:||
Zfish   353 GEVEHATGRTCAVRTACRYDPRVNRWTEIAPMKACREHFVLGALGQYLYAVGGRNELRQVLPSVE 417

  Fly   405 VYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYALGGHDGLSIFDS-VERYDQAEDVWVKMSPMLN 468
            .|.||.|.|..|....:..|.......:|.::..||....:.:.: :..||..::.|:..||||.
Zfish   418 RYCPKRNKWTYVQPFDRSLSCHAGCVADGLLWVSGGVTNTAQYQNRLMVYDPGQNQWLARSPMLQ 482

  Fly   469 RRCRLGVATLNGKIYVCGG----YCGNSFL-RSVECYDPQTDTW-----KLVTPMNCKRSRVALA 523
            ||....:|.:..::||.||    |..:..| |.::.||...|.|     .|:|..|    ...::
Zfish   483 RRVYHVMAAVKRQLYVLGGNDLDYNNDRILVRHIDSYDIDMDQWTRCTFSLLTGQN----EAGVS 543

  Fly   524 ANMGKLWAIGGYDGESN--LSTVEVYDPET---DKWTFMPPMCAHSGGV 567
            .:..:::.:|||...:|  |:.::|.|..|   ::..:.|.:...|.||
Zfish   544 VHDDRIYVVGGYSIWTNEPLACIQVLDVSTKGKEEVFYGPTLPFASNGV 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	37/103 (36%)
		PHA03098	36..510	CDD:222983	146/502 (29%)
		KELCH repeat	329..372	CDD:276965	17/47 (36%)
		KELCH repeat	376..417	CDD:276965	14/41 (34%)
		KELCH repeat	423..466	CDD:276965	8/43 (19%)
		KELCH repeat	470..514	CDD:276965	15/53 (28%)
		Kelch_1	517..560	CDD:396078	9/47 (19%)
		KELCH repeat	517..560	CDD:276965	9/47 (19%)
klhl32	NP_001076491.1	BTB_POZ_KLHL32	14..146	CDD:349570	38/111 (34%)
		BACK	139..236	CDD:475122	24/98 (24%)
		Kelch	291..345	CDD:128874	13/53 (25%)
		NanM	324..595	CDD:442289	75/273 (27%)
		KELCH repeat	336..384	CDD:276965	17/47 (36%)
		KELCH repeat	388..433	CDD:276965	15/44 (34%)
		KELCH repeat	436..482	CDD:276965	10/45 (22%)
		KELCH repeat	484..534	CDD:276965	13/49 (27%)