Protein Alignment KLHL18 and kbtbd3

DIOPT Version :10

• Sequence 1: NP_650143.1
• Gene: KLHL18 / 41458
• FlyBaseID: FBgn0037978
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_073780249.1
• Gene: kbtbd3 / 100003277
• ZFINID: ZDB-GENE-131016-5
• Length: 615
• Species: Danio rerio
• Alignment Length: 590
• Identity: 156/590 - (26%)
• Similarity: 248/590 - (42%)
• Gaps: 66/590 - (11%)

  Fly     9 VEDQYFVYKHDKLFGES-FPLFKEIRRMGKLCDVTLKVEDQTFSAHRVVLAATIPYFYAMFTNNM 72
            |..|..|:...:..|:. ..:.:..|:...|.|.::.|:|:|...||.||||...:|.|||..:|
Zfish    23 VSPQRCVFLRCECVGQQIISVLQGFRQRKLLLDFSIHVQDETLLCHRCVLAACSHFFRAMFELDM 87

  Fly    73 AESRIKEITMKESAIEPSALESLINYVYSGQVRIDNQNVQNLMVGASFLQLSNVRDACASFLISR 137
            .|.....:|:  |.:...|:.:.:::.|||::.:...||:.|...|||||:..:..:|:.||:..
Zfish    88 RECVDGSVTL--SNLSAQAVHTFLDFAYSGEIEVREDNVEMLFQMASFLQVDFLLRSCSDFLLES 150

  Fly   138 FHPHNVLGIRTFADSMICRQLIDAADKYIDQNFAKVSQSEEFLALDCEQLLELMRRDELNVRTEE 202
            ....|.|.:...|:.....||:..|..:|.|||..||.|.|||.|....|..::..|||.|..||
Zfish   151 LDVSNCLHLLELAEGYGSTQLLRGAIDFITQNFQTVSCSVEFLELPSPVLERVLLSDELRVPDEE 215

  Fly   203 VIFEACMKWVKYAEDKRSELFPQVLAAVRLPLLSPQFLADRVAREELIRSSHQCRDLLDEAKDFH 267
            .:.:|.:.|||:....|:.|..|:||.|||..: |....:..|:.:::  :.:||::|..|
Zfish   216 TVLQALLCWVKHDPSTRTSLMQQLLACVRLHHI-PIATLENAAQSDML--TDECRNMLTHA---- 273

  Fly   268 LMPERRGLLQSFRTRQRSGEFFTGQIYAVGG---LASTGESVSTVEIYDPLTKKWKMGEQMSMMR 329
                   |.|   |:|.||.|...::.....   :..|.||:.....|:.::.:|....:.:|..
Zfish   274 -------LAQ---TQQFSGLFTDARVSTTSTYIFVHKTEESMRHTFCYEIVSDRWTPLPEDAMRI 328

  Fly   330 SRVGVAVLNG---KLYAFGGFNGT--------------ERLSTVEVYDPRKNKWSQGCAMLCKRS 377
            ..:..:|:..   ||:..||.:..              |.......|.|..:.::....|...|:
Zfish   329 LELPGSVMTSFAEKLFISGGCHSDCPRSIRTHISSPHHEATDEFWCYCPIAHSFTPAPRMRHTRT 393

  Fly   378 A-VGVAALDDCIYVCGGYD----GVTSLNTVEVYYPKSNTWKTVAQMMKYRSAGGVTQLNGYVYA 437
            . ..|.||.. :||.||..    .|.|:..|:.|.|....|.:|:.:.|.......:.....:||
Zfish   394 MHTCVVALQR-LYVIGGKPRSSRNVPSIVDVDYYDPLMREWISVSPLPKGIYFPEASVCGNVIYA 457

  Fly   438 LGGHDGLS-----IFDSVERYDQAEDVW----VKMSPMLNRRCRLGVATLNGKIYVC--GGYCGN 491
            ||.....|     :.|...|||...|.|    .:.....:.|....|. :|..:|:|  ..|...
Zfish   458 LGSEVEFSDAFNPLLDCFFRYDAVADQWSHLVAEFGQFFHARLVKSVC-VNETLYLCDLSTYKVY 521

  Fly   492 SFLRSVECYDPQTDTWKLVTPMNCKRSRVALAANMGKLWAIGG-YDGESNLSTVEVYDPETDKWT 555
            ||     |.|  ...||......|.....|.....||::.:|| |..:.....|:|||....:|.
Zfish   522 SF-----CAD--EGVWKGEGSFECAGFNAAAVGVRGKIFILGGDYSPDEISDEVQVYDSSRSEWQ 579

  Fly   556 FMPPM 560
            .:.||
Zfish   580 EVSPM 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL18	NP_650143.1	BTB_POZ_KLHL18	20..137	CDD:349556	36/117 (31%)
		PHA03098	36..510	CDD:222983	137/509 (27%)
		KELCH repeat	329..372	CDD:276965	8/59 (14%)
		KELCH repeat	376..417	CDD:276965	14/45 (31%)
		KELCH repeat	423..466	CDD:276965	11/51 (22%)
		KELCH repeat	470..514	CDD:276965	12/45 (27%)
		Kelch_1	517..560	CDD:396078	11/43 (26%)
		KELCH repeat	517..560	CDD:276965	11/43 (26%)
kbtbd3	XP_073780249.1	None