Protein Alignment Ect3 and GLB1L

DIOPT Version :9

• Sequence 1: NP_650142.1
• Gene: Ect3 / 41457
• FlyBaseID: FBgn0260746
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_001273352.1
• Gene: GLB1L / 79411
• HGNCID: 28129
• Length: 654
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 271/635 - (42%)
• Similarity: 375/635 - (59%)
• Gaps: 26/635 - (4%)

  Fly     6 VVLVALLPLLGAVSANRTFVVDYEKDQFLKDGEPFRFIAGSFHYFRAHPATWQRHLRTMRAAGLN 70
            ::|...|.||...:..|:||||...|:||.||.|||:::||.||||.....|...|..||.:|||
Human    12 LLLPLSLTLLLPQADTRSFVVDRGHDRFLLDGAPFRYVSGSLHYFRVPRVLWADRLLKMRWSGLN 76

  Fly    71 AVTTYVEWSLHNPRDGVYVWSGIADLEHFIRLAVGEDLLVILRPGPYICAERDMGGFPYWLLNKY 135
            |:..||.|:.|.|:.|||.::|..||..|:..|...:||||||||||||||.:|||.|.|||.|
Human    77 AIQFYVPWNYHEPQPGVYNFNGSRDLIAFLNEAALANLLVILRPGPYICAEWEMGGLPSWLLRK- 140

  Fly   136 PGIQLRTADVNYLSEIRIWYTQLFAKMNKYLYGNGGPIIMVQVENEYGSFYACDLNYRNWLRDET 200
            |.|.|||:|.::|:.:..|:..|..|:..:||.|||.||.:||||||||:.|||.:|...|....
Human   141 PEIHLRTSDPDFLAAVDSWFKVLLPKIYPWLYHNGGNIISIQVENEYGSYRACDFSYMRHLAGLF 205

  Fly   201 ESHVKGQAVLFTNDGPSVLRCGKIQGVLATMDFGATNDLKPIWAKFRRYQPKGPLVNAEYYPGWL 265
            .:.:..:.:|||.|||..|:||.::|:..|:|||..:::..|:...|:|:|.|||||:|||.|||
Human   206 RALLGEKILLFTTDGPEGLKCGSLRGLYTTVDFGPADNMTKIFTLLRKYEPHGPLVNSEYYTGWL 270

  Fly   266 THWTEPMANVSTQSITSTFINMLDHGASVNFYMFYGGTNFGFTAGANDIGPGNYMADITSYDYDA 330
            .:|.:..:..|..::|....|||..|||||.|||:||||||:..||:.  .|.::...|||||||
Human   271 DYWGQNHSTRSVSAVTKGLENMLKLGASVNMYMFHGGTNFGYWNGADK--KGRFLPITTSYDYDA 333

  Fly   331 PMTEAGDPTPKYQALRRIIGRYLPLPNQPVPGPVPKRSYGTVRLTTCCSLLSSEARSRLSTGFVQ 395
            |::||||||||..|||.:|.::..:|..|:|.|.||...|.|.|.....||:. .......|.:.
Human   334 PISEAGDPTPKLFALRDVISKFQEVPLGPLPPPSPKMMLGPVTLHLVGHLLAF-LDLLCPRGPIH 397

  Fly   396 SAKPKSFEALGQYSGLVLYETWLPSFQRDPSILSVP--GLADRGYVYVDGEFVGILARETPVFEL 458
            |..|.:|||:.|..|.:||.|::.....:|:...||  |:.||.||.|||.|.|::.|... .:|
Human   398 SILPMTFEAVKQDHGFMLYRTYMTHTIFEPTPFWVPNNGVHDRAYVMVDGVFQGVVERNMR-DKL 461

  Fly   459 PLSASAGRRFQIIVENQGRINYGRQLNDFKGILRDVRLDKQVLSNWNMTQFPLESYDNLEQLITQ 523
            .|:...|.:..|:|||.||:::|...:||||:|:...|.:.:|:.|.|  |||: .|||
Human   462 FLTGKLGSKLDILVENMGRLSFGSNSSDFKGLLKPPILGQTILTQWMM--FPLK-IDNL------ 517

  Fly   524 SDEAVRQGF--QELKKLRTMLRTGPAIYHGQLDIQKESDLADTYLDMSGWGKGIVFVNGENLGRY 586
                |:..|  |..|.......:||..|.....|.  ..:.||:|.:.||.||.|::||.|||||
Human   518 ----VKWWFPLQLPKWPYPQAPSGPTFYSKTFPIL--GSVGDTFLYLPGWTKGQVWINGFNLGRY 576

  Fly   587 WPLVGPQVTLYVPAAVL--KAGSNRLVVVEYQQTPASQELHFRDTPILNA 634
            |...|||.|||||..:|  :...|::.::|.:..|...::.|.|.||||:
Human   577 WTKQGPQQTLYVPRFLLFPRGALNKITLLELEDVPLQPQVQFLDKPILNS 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ect3	NP_650142.1	Glyco_hydro_35	32..350	CDD:279624	157/317 (50%)
		BetaGal_dom4_5	<576..616	CDD:290101	20/41 (49%)
GLB1L	NP_001273352.1	Glyco_hydro_35	38..353	CDD:307464	157/317 (50%)
		BetaGal_dom4_5	527..605	CDD:315929	31/79 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153133
Domainoid	1	1.000	327	1.000	Domainoid score	I1171
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75208
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1401
Isobase	1	0.950	-	0	Normalized mean entropy	S4187
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm8540
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	LDO	PTHR23421
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5429
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750