DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ect3 and Glb1l2

DIOPT Version :9

Sequence 1:	NP_650142.1	Gene:	Ect3 / 41457	FlyBaseID:	FBgn0260746	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_038937926.1	Gene:	Glb1l2 / 503194	RGDID:	1564436	Length:	751	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	229/622 - (36%)
Similarity:	320/622 - (51%)	Gaps:	70/622 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FLKDGEPFRFIAGSFHYFRAHPATWQRHLRTMRAAGLNAVTTYVEWSLHNPRDGVYVWSGIADLE 97
            |:.:...|:.:.||.||||.....|:..|..::|.|||.:||||.|:||.|..|.:.:||..|||
  Rat   110 FMLEDSTFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLE 174

  Fly    98 HFIRLAVGEDLLVILRPGPYICAERDMGGFPYWLLNKYPGIQLRTADVNYLSEIRIWYTQLFAKM 162
            .||.||....|.||||||||||:|.|:||.|.|||.. |.::|||....:...:.:::..|.:::
  Rat   175 AFIWLAAKIGLWVILRPGPYICSEIDLGGLPSWLLQD-PDMKLRTTYPGFTKAVDLYFDHLMSRV 238

  Fly   163 NKYLYGNGGPIIMVQVENEYGSFYACDLNYRNWLRDETESHVKG-QAVLFTNDGPSVLRCGKIQG 226
            ....|.:|||||.||||||||| |..|..|..:::...|.  :| ..:|.|:|....|..|.:.|
  Rat   239 VPLQYKHGGPIIAVQVENEYGS-YNGDHAYMPYIKKALED--RGIIEMLLTSDNKDGLEKGVVDG 300

  Fly   227 VLATMDFGATND---LKPIWAKFRRYQPKGPLVNAEYYPGWLTHWTEPMANVSTQSITSTFINML 288
            ||||::..:..:   |..|....:..|||   :..||:.||...|......:.:..:..|...::
  Rat   301 VLATINLQSQQELVALNSILLSIQGIQPK---MVMEYWTGWFDSWGGSHNILDSSEVLQTVSAII 362

  Fly   289 DHGASVNFYMFYGGTNFGFTAGANDIGPGNYMADITSYDYDAPMTEAGDPTPKYQALRRIIGRYL 353
            ..|:|:|.|||:|||||||..||...  |:|.||:|||||||.:|||||.|.||..||.:.|.:.
  Rat   363 KDGSSINLYMFHGGTNFGFINGAMHF--GDYKADVTSYDYDAILTEAGDYTAKYTKLRELFGTFS 425

  Fly   354 PLPNQPVPGPVPKRSYGTVR----LTTCCSLLSSEARSRLSTGFVQSAKPKSFEAL------GQY 408
            .:|..|.|....|..|..|.    |:...:||..:..       :.|..|.:.|.|      ||.
  Rat   426 GVPPPPPPELTAKMVYEPVTPSFYLSLWDALLYMDKP-------ITSEIPINMENLPVNNGNGQA 483

  Fly   409 SGLVLYETWLPSFQRDPSILSVPGLA-DRGYVYVDGEFVGILARETPVFELPLSASAGRRFQIIV 472
            .|.|||||.:.|    ..:||  ||. |||.|:::...:|.|...|....:||: ......:|:|
  Rat   484 FGYVLYETTIFS----SGVLS--GLVRDRGQVFLNRVSIGFLDYTTTKITIPLT-QGYTILRILV 541

  Fly   473 ENQGRINYGRQL-NDFKGILRDVRLDKQVLSNWNMTQFPLESYDNLEQLITQSDEAVRQGFQELK 536
            ||:||:|||..: :..||::.::.|:.:.|.|     |.:.|.|..:|...:.|         :.
  Rat   542 ENRGRVNYGNNIDSQRKGLIGNLYLNNKPLKN-----FKIYSLDMTKQFFQRFD---------MD 592

  Fly   537 KLRTMLR--TGPAIYHGQLDIQKESDLADTYLDMSGWGKGIVFVNGENLGRYWPLVGPQVTLYVP 599
            |...:.:  |.||.:.|.|.:....  :||:|.:.||.||:|.||..||||||. ||||.|||:|
  Rat   593 KWSVVPKEITFPAFFLGTLSVGIYP--SDTFLKLEGWVKGVVLVNDHNLGRYWN-VGPQETLYLP 654

  Fly   600 AAVLKAGSNRLVVVEYQQTPASQEL--------HFRD 628
            ...|..|.|:.|    |.|.|.|..        |.||
  Rat   655 GVWLDKGLNKHV----QPTLALQHRLVLPGPVNHIRD 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ect3	NP_650142.1	Glyco_hydro_35	32..350	CDD:279624	133/320 (42%)
Ect3	NP_650142.1	BetaGal_dom4_5	<576..616	CDD:290101	21/39 (54%)
Glb1l2	XP_038937926.1	Glyco_hydro_35	109..422	CDD:396048	133/320 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660