DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ect3 and Glb1

DIOPT Version :9

Sequence 1:	NP_650142.1	Gene:	Ect3 / 41457	FlyBaseID:	FBgn0260746	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001101662.1	Gene:	Glb1 / 316033	RGDID:	1597145	Length:	647	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	292/650 - (44%)
Similarity:	396/650 - (60%)	Gaps:	40/650 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVALLPLLGAVS-----ANRTFVVDYEKDQFLKDGEPFRFIAGSFHYFRAHPATWQRHLRTMRAA 67
            |:|||.||||..     :.|||.:||::|:|||||:|||:|:||.||||.....|:..|..|:.|
  Rat    12 LLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMA 76

  Fly    68 GLNAVTTYVEWSLHNPRDGVYVWSGIADLEHFIRLAVGEDLLVILRPGPYICAERDMGGFPYWLL 132
            ||:|:.|||.|:.|.|:.|.|.:||..|:||||:||....||||||||||||||.||||.|.|||
  Rat    77 GLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLL 141

  Fly   133 NKYPGIQLRTADVNYLSEIRIWYTQLFAKMNKYLYGNGGPIIMVQVENEYGSFYACDLNYRNWLR 197
            .| ..|.||::|.:||:.:..|...|..||.:.||.||||||.|||||||||::|||.||..:|.
  Rat   142 EK-ESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLE 205

  Fly   198 DETESHVKGQAVLFTNDGPS--VLRCGKIQGVLATMDFGATNDLKPIWAKFRRYQPKGPLVNAEY 260
            .....|:....:|||.||.:  :|:||.:|.:.||:|||.|.::...:...|.::|||||:|:|:
  Rat   206 HRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEF 270

  Fly   261 YPGWLTHWTEPMANVSTQSITSTFINMLDHGASVNFYMFYGGTNFGFTAGANDIGPGNYMADITS 325
            |.|||.||.:|.:.|:|:.:.::..|:|.:|||||.|||.|||||.:..|||    ..|....||
  Rat   271 YTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNGAN----MPYAPQPTS 331

  Fly   326 YDYDAPMTEAGDPTPKYQALRRIIGRYLPLPNQPVPGPVPKRSYGTVRLTTCCSLLSSEARSRL- 389
            ||||||::||||.|.||.|:|.:|.::..:|..|:|...||.:||.|.|....::  :||...|
  Rat   332 YDYDAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFKTV--TEALGILC 394

  Fly   390 STGFVQSAKPKSFEALGQYSGLVLYETWLPSFQRDPS-ILSVP--GLADRGYVYVDGEFVGILAR 451
            ..|.|:|..|.:|..:.||.|.|||.|.||....:|. |.|.|  |:.||.||.|||...|||.|
  Rat   395 PNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVSVDGVPQGILDR 459

  Fly   452 ETPVFELPLSASAGRRFQIIVENQGRINYGRQLNDFKGILRDVRLDKQVLSNWNMTQFPLESYDN 516
            .. :..|.:...||....|:|||.||:|||..:.||||::.::.|:..||:||  |.|||::
  Rat   460 NR-MNVLNIRGKAGATLDILVENMGRVNYGNSIKDFKGLISNMTLNFTVLTNW--TMFPLDT--- 518

  Fly   517 LEQLITQSD----EAVRQGFQE-LKKLRTMLRTGPAIYHGQLDIQKE-SDL-ADTYLDMSGWGKG 574
              :.:.:|.    ||..:|..: ...||:...|.|..|.|...|... .|| .||::...||.||
  Rat   519 --EALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPDLPQDTFIQFPGWAKG 581

  Fly   575 IVFVNGENLGRYWPLVGPQVTLYVPAAVLKAGS-NRLVVVEYQQTPASQ------ELHFRDTPIL 632
            .|::||.|||||||..|||:||:||..:|...: |.:.|:|.:.:|.|.      .:.|.|||::
  Rat   582 QVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELESSPCSNGTLELCTVEFVDTPVI 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ect3	NP_650142.1	Glyco_hydro_35	32..350	CDD:279624	164/319 (51%)
Ect3	NP_650142.1	BetaGal_dom4_5	<576..616	CDD:290101	21/40 (53%)
Glb1	NP_001101662.1	Glyco_hydro_35	41..356	CDD:279624	164/319 (51%)
Glb1	NP_001101662.1	BetaGal_dom4_5	<553..621	CDD:290101	30/67 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346750
Domainoid	1	1.000	336	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	513	1.000	Inparanoid score	I1255
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm9014
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	O	PTHR23421
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770