DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ect3 and Glb1l

DIOPT Version :9

Sequence 1:	NP_650142.1	Gene:	Ect3 / 41457	FlyBaseID:	FBgn0260746	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001121001.1	Gene:	Glb1l / 301525	RGDID:	1309474	Length:	646	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	271/645 - (42%)
Similarity:	379/645 - (58%)	Gaps:	44/645 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SVVVLVALLPLLGAVSANRTFVVDYEKDQFLKDGEPFRFIAGSFHYFRAHPATWQRHLRTMRAAG 68
            |:::.:.:|.||....| |:||||.:.|:||.||.|||:|:||.||||.....|...|..|:.:|
  Rat     7 SLLLRLVILLLLSQAEA-RSFVVDRQHDRFLLDGVPFRYISGSLHYFRVPRVLWADRLLKMKLSG 70

  Fly    69 LNAVTTYVEWSLHNPRDGVYVWSGIADLEHFIRLAVGEDLLVILRPGPYICAERDMGGFPYWLLN 133
            ||||..||.|:.|.|..|:|.::|..||..|:..|...:||||||||||||||.:|||.|.|||
  Rat    71 LNAVQFYVPWNYHEPEPGIYNFNGSRDLTAFLNEAAKANLLVILRPGPYICAEWEMGGLPSWLL- 134

  Fly   134 KYPGIQLRTADVNYLSEIRIWYTQLFAKMNKYLYGNGGPIIMVQVENEYGSFYACDLNYRNWLRD 198
            :...|.|||:|..:|..:..|:..|..|:..:||.|||.||.:||||||||:..||..|...|..
  Rat   135 RNRDIHLRTSDPAFLHAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYKVCDFKYMRHLAG 199

  Fly   199 ETESHVKGQAVLFTNDGPSVLRCGKIQGVLATMDFGATNDLKPIWAKFRRYQPKGPLVNAEYYPG 263
            ...:.:..:.:|||.|||..||||.:||:.||:|||..:::..|::..|.|:|.|||||:|||.|
  Rat   200 LFRALLGDEILLFTTDGPQGLRCGSLQGLYATVDFGPADNVTRIFSLLREYEPHGPLVNSEYYTG 264

  Fly   264 WLTHWTEPMANVSTQSITSTFINMLDHGASVNFYMFYGGTNFGFTAGANDIGPGNYMADITSYDY 328
            ||.:|.:..:..||.::......:|..|||||.|||:||||||:..||:|  .|.::...|||||
  Rat   265 WLDYWGQNHSTRSTPAVARGLERILKLGASVNMYMFHGGTNFGYWNGADD--KGYFLPITTSYDY 327

  Fly   329 DAPMTEAGDPTPKYQALRRIIGRYLPLPNQPVPGPVPKRSYGTVRLTTCCSLLS------SEARS 387
            |||::||||||||..|::.:|.::..:|..|:|.|.||...|.:.::...:|||      .|
  Rat   328 DAPISEAGDPTPKLFAIQNVISKFQEIPLGPLPPPSPKMKLGPLTMSLDGNLLSFLDFLCPE--- 389

  Fly   388 RLSTGFVQSAKPKSFEALGQYSGLVLYETWLPSFQRDPSILSVP--GLADRGYVYVDGEFVGILA 450
                |.:.|..|.:|||:....|.:||.|::.....:|:.|.||  |:.||.||.|||...|||.
  Rat   390 ----GPIHSVLPLTFEAVKLDRGFMLYRTYMTYTVSEPTPLWVPNNGIHDRAYVMVDGVLKGILE 450

  Fly   451 RETPVFELPLSASAGRRFQIIVENQGRINYGRQLNDFKGILRDVRLDKQVLSNWNMTQFPLESYD 515
            |.... ||.|:...|.|..|::||.||:::|...:||||:|....|.:.||:.|.|  |||
  Rat   451 RSLKE-ELYLTGKVGTRLDILLENMGRLSFGSNHSDFKGLLEPPLLGQTVLTGWMM--FPL---- 508

  Fly   516 NLEQLITQSDEAVRQ--GFQELKKLRTMLRTGPAIYHGQ---LDIQKESDLADTYLDMSGWGKGI 575
                   :.|:.|:.  ..|.:|:.:....:.||.|..:   |.:     |.||:|.:.||.||.
  Rat   509 -------KVDKLVKWWIPLQLMKRAQPQAPSVPAFYSAKFPALGL-----LGDTFLYLPGWTKGQ 561

  Fly   576 VFVNGENLGRYWPLVGPQVTLYVPAAVLKAGS-NRLVVVEYQQTPASQELHFRDTPILNA 634
            |::||.||||||.:.|||.|||||..:|...| |::.::|.:..|...::.|.|.||||:
  Rat   562 VWINGFNLGRYWTMRGPQQTLYVPRPLLFGSSINKITLLELEDVPHDPQIQFLDKPILNS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ect3	NP_650142.1	Glyco_hydro_35	32..350	CDD:279624	154/317 (49%)
Ect3	NP_650142.1	BetaGal_dom4_5	<576..616	CDD:290101	21/40 (53%)
Glb1l	NP_001121001.1	Glyco_hydro_35	34..349	CDD:279624	154/317 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346744
Domainoid	1	1.000	336	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_COG1874
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75208
Inparanoid	1	1.050	513	1.000	Inparanoid score	I1255
OMA	1	1.010	-	-		QHG52178
OrthoDB	1	1.010	-	-		D179316at2759
OrthoFinder	1	1.000	-	-		FOG0002046
OrthoInspector	1	1.000	-	-		mtm9014
orthoMCL	1	0.900	-	-		OOG6_100579
Panther	1	1.100	-	-	LDO	PTHR23421
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1174
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770