DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mfas and tgfbi

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001072329.1	Gene:	tgfbi / 779782	XenbaseID:	XB-GENE-5751247	Length:	677	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	160/726 - (22%)
Similarity:	295/726 - (40%)	Gaps:	161/726 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTKI 264
            |||||..::                ..|..:...||                |.:...:.:|
Frog    40 GPNVCAVQK----------------LIGTNKQYYTN----------------CKQWYQRKIC--- 69

  Fly   265 VNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEK-----IDIKDVEATASDMGAKQFLESARTAG 324
                  .|:..::.:||.||.|       .|.||     :.:.::..|...:||......:..|.
Frog    70 ------GKSTIISYECCPGYER-------VPGEKGCPAALPLSNIYETLGVVGAATTQLYSDRAN 121

  Fly   325 ELADMLGAGSGKKVTLFVPNDAAFMEYRGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQLE--- 386
            ...::.|.||   .|:|.|::.|:                   |:.|:.. |.|::..|.:|
Frog   122 LRPEIEGPGS---FTIFAPSNEAW-------------------AALPAEI-LDALVSNVNIELLN 163

  Fly   387 ----DVPNEKLLQTELPD--------QKIRINSYQLPAALGLEPYRFAANCVPIEKHDKLSEQAL 439
                .:.|.:||..||..        |.:.|:.:..|..:      ...||..:.|.|..:...:
Frog   164 ALRYHMVNRRLLTDELKHGVTFPSMYQNLDIHVHHYPNGI------VTVNCARLIKADHHATNGV 222

  Fly   440 VHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLED-DKPVTIFVPTDAAFDKLEPH- 502
            ||.:..|:..:|.::..::.....:..:||.:..:.|:.:||. :|..|:..||:.||:|:.|.
Frog   223 VHVIDKVITAVTNDINQVVETEESLETLRTAVAASGLNTLLESLNKQYTLLAPTNEAFEKIPPET 287

  Fly   503 LRRALKEGRGCASNILKNHLLDLTFCSLATVPGAK-------TTAYNLLGEPLLLNRTHRAANQT 560
            |.|.|.:.. ...::|.:|:|:...||.|.:.|:.       :......||.|.||
Frog   288 LNRILGDPE-ALKDLLHHHILNNAQCSEAIIAGSSMETLEGTSIEVGCTGEDLTLN--------- 342

  Fly   561 GPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQF 625
             ..||       |...||:.||||:|.||.:|..::|..::.|....:.:....|.:.:|.....
Frog   343 -GKPI-------ISRKDILATNGVVHFIDELLIPDAAKTLSELGKDSDASKVIELFQQAGLGSHL 399

  Fly   626 DDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPMIKTCDLSE-KSLPTV 689
            ...:.||:.|..:.|.::        ..|.:   |.||...|..|::|..:.:..|.. :.|.||
Frog   400 AVNERVTVIAAHNNAFKD--------RTPSV---NRDLTNLLQNHIIKETLSSKYLYHGQVLETV 453

  Fly   690 AGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPN 754
            .|..:|:.:|         .|...:..:.:...|.:.....|..||:.|.||..|::.:|:|:..
Frog   454 GGKKLRVFVY---------RNALCIENSCIDAHDKKGRYGTLFIVDKLLTPPTGNVMDVLKADNR 509

  Fly   755 YSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFE-----ELNESGEGSKPADPMALVKTHIVED 814
            :|..:..::.|.||:.|:.:. :.|:..|.::.|.     |||:....:|  |...|:|.||.::
Frog   510 FSMLVAAIQSAGLTETLNREG-TFTVFAPTDEAFRALPRGELNKLLGNAK--DLSNLLKYHIGDE 571

  Fly   815 VVCCAGIIPTNWPFVRSIESISGQHLRIT-RDRRPKIENAGVTKCDVVATNGILHEINDIIVPRP 878
            ::....:.    ..|| ::|:.|:.|..| ::....|....:::.|::||||::|.:...:  .|
Frog   572 ILVSGAVS----QLVR-LKSLQGEKLEATSKNATMHINKVPISEADMMATNGVIHAVRTFL--HP 629

  Fly   879 QRQQQQRPQLI 889
            ..:.|:|..|:
Frog   630 PAKTQERGDLM 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	25/125 (20%)
		Fasciclin	462..592	CDD:280607	40/138 (29%)
		Fasciclin	607..740	CDD:280607	26/133 (20%)
		Fasciclin	753..875	CDD:280607	30/127 (24%)
tgfbi	NP_001072329.1	Fasciclin	112..230	CDD:367095	28/146 (19%)
		Fasciclin	249..368	CDD:367095	41/136 (30%)
		Fasciclin	381..495	CDD:367095	26/133 (20%)
		Fasciclin	509..629	CDD:367095	30/129 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11271
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37294
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4426
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm48074
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970