Protein Alignment mfas and TGFBI

DIOPT Version :10

• Sequence 1: NP_788655.1
• Gene: mfas / 41455
• FlyBaseID: FBgn0260745
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: NP_000349.1
• Gene: TGFBI / 7045
• HGNCID: 11771
• Length: 683
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 160/729 - (21%)
• Similarity: 295/729 - (40%)
• Gaps: 137/729 - (18%)

  Fly   191 GAAQEPW------------WKGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFG 243
            |.|:.|:            ..|||||..::                ..|..|...||
Human    24 GPAKSPYQLVLQHSRLRGRQHGPNVCAVQK----------------VIGTNRKYFTN-------- 64

  Fly   244 QFQFSVNSCAEKPNKHVCTKIVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEK-----IDIKD 303
                    |.:...:.:|         .|:..::.:||.||.:       .|.||     :.:.:
Human    65 --------CKQWYQRKIC---------GKSTVISYECCPGYEK-------VPGEKGCPAALPLSN 105

  Fly   304 VEATASDMGAKQF-LESARTAGELADMLGAGSGKKVTLFVPNDAAF----MEYRGHHQQENNVED 363
            :..|...:|:... |.:.||.....:|.|.||   .|:|.|::.|:    .|.........|:|.
Human   106 LYETLGVVGSTTTQLYTDRTEKLRPEMEGPGS---FTIFAPSNEAWASLPAEVLDSLVSNVNIEL 167

  Fly   364 AKAEASKPSIYKLHAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPI 428
            ..|       .:.|.|...|..:::.:...|.:...:..|:|:.|  |..:      ...||..:
Human   168 LNA-------LRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHY--PNGI------VTVNCARL 217

  Fly   429 EKHDKLSEQALVHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTD 493
            .|.|..:...:||.:..|:..:|.|:..||........:|..:..:.|:.|||.:...|:..||:
Human   218 LKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTN 282

  Fly   494 AAFDKLEPH-LRRALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNLLGEPLLLNRTHRAA 557
            .||:|:... |.|.|.:.. ...::|.||:|....|:.|.|.|.....         |..|....
Human   283 EAFEKIPSETLNRILGDPE-ALRDLLNNHILKSAMCAEAIVAGLSVET---------LEGTTLEV 337

  Fly   558 NQTGPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYD 622
            ..:|.. :.||..|.|.:.||:.||||:|.||.:|..:||..:..|.::.:::....|...:|..
Human   338 GCSGDM-LTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLG 401

  Fly   623 DQFDDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPMIKTCDLSE-KSL 686
            :.....:.:|:.||.:...::        ..|.:..|..:|   |..|::|..:.:..|.. ::|
Human   402 NHLSGSERLTLLAPLNSVFKD--------GTPPIDAHTRNL---LRNHIIKDQLASKYLYHGQTL 455

  Fly   687 PTVAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEA 751
            .|:.|..:|:.:|         .|...:..:.:...|.......|..:||.|.||...::.:|:.
Human   456 ETLGGKKLRVFVY---------RNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKG 511

  Fly   752 NPNYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFEELNES------GEGSKPADPMALVKTH 810
            :..:|..:..::.|.||:.|:.:. ..|:..|.|:.|..|...      |:..:.|:   ::|.|
Human   512 DNRFSMLVAAIQSAGLTETLNREG-VYTVFAPTNEAFRALPPRERSRLLGDAKELAN---ILKYH 572

  Fly   811 IVEDVVCCAGIIPTNWPFVRSIESISGQHLRIT-RDRRPKIENAGVTKCDVVATNGILHEINDII 874
            |.::::...||    ...|| ::|:.|..|.:: ::....:....|.:.|::||||::|.|.:::
Human   573 IGDEILVSGGI----GALVR-LKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVL 632

  Fly   875 VPRPQRQQQQRPQL 888
            .|...|.|::..:|
Human   633 QPPANRPQERGDEL 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	23/114 (20%)
		Fasciclin	462..592	CDD:396845	38/130 (29%)
		Fasciclin	607..740	CDD:396845	23/133 (17%)
		Fasciclin	753..875	CDD:396845	30/128 (23%)
TGFBI	NP_000349.1	Fasciclin	133..236	CDD:396845	25/120 (21%)
		Fasciclin	253..373	CDD:396845	39/130 (30%)
		Fasciclin	386..500	CDD:396845	23/133 (17%)
		Fasciclin	514..634	CDD:396845	30/128 (23%)
		Cell attachment site. /evidence=ECO:0000255	642..644		0/1 (0%)