DRSC/TRiP Functional Genomics Resources

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Protein Alignment mfas and STAB2

DIOPT Version :9

Sequence 1:NP_788655.1 Gene:mfas / 41455 FlyBaseID:FBgn0260745 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_060034.9 Gene:STAB2 / 55576 HGNCID:18629 Length:2551 Species:Homo sapiens


Alignment Length:343 Identity:89/343 - (25%)
Similarity:139/343 - (40%) Gaps:93/343 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   418 PYRFAANCVP---------------IEKHDKLSEQALVHTLGGVLKPLT---KNLMDIIRERADM 464
            |.:.|.||:|               :.|:...||.|:.:..|.|.:..|   ..:.|....|.  
Human  1535 PNQAACNCLPAYTGDGKVC
TLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRG-- 1597

  Fly   465 SIMRTVLEKTNLSAM-----------LEDDKPVTIFVPTDAAFDKLEPHLRRALKEGR------- 511
            ||.:.:.:....|..           |....|.|:|.|..||||          :|.|       
Human  1598 SIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFD----------EEARVKDWDKY 1652

  Fly   512 GCASNILKNHLLDLTFCSLATVPGAK--TTAYNLLGEPLLLNRTHRAANQTGPTPIYINNLAKII 574
            |....:|:.|::   .|....:...|  :.|.:|.|||::::        ...:.:||||.||||
Human  1653 GLMPQVLRYHVV---ACHQLLLENLKLISNATSLQGEPIVIS--------VSQSTVYINNKAKII 1706

  Fly   575 DADIMGTNGVLHVIDTILPTESAL------------PMTSLMSQKNLTIFQRLLEASGYDDQFDD 627
            .:||:.|||::|:||.:|..::.|            .:|:|.:......|..|::.||......|
Human  1707 SSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITD 1771

  Fly   628 LDN--VTIFAPTDKALQNTEWARMLKEQPELLNH-NLD-LLEFLNYHVVK------------PMI 676
            ..:  ||:|.|||:||.    |...::|..|.|. |.| |.|:|.:||::            ...
Human  1772 PIHTPVTLFWPTDQALH----ALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAW 1832

  Fly   677 KTCDLSEKSLPTVAGSSV 694
            ||...||.|:...||..:
Human  1833 KTLQGSELSVKCGAGRDI 1850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mfasNP_788655.1 FAS1 339..450 CDD:214719 11/46 (24%)
Fasciclin 462..592 CDD:280607 40/149 (27%)
Fasciclin 607..740 CDD:280607 31/104 (30%)
Fasciclin 753..875 CDD:280607
STAB2NP_060034.9 EGF_3 246..275 CDD:289699
EGF_3 326..361 CDD:289699
Fasciclin 382..505 CDD:280607
Fasciclin 526..654 CDD:280607
EGF_3 837..865 CDD:289699
EGF_3 920..951 CDD:289699
EGF_3 957..993 CDD:289699
Fasciclin 1009..1129 CDD:280607
Fasciclin 1148..1265 CDD:280607
EGF_3 1437..1469 CDD:289699
EGF_3 1475..1511 CDD:289699
EGF_3 1517..1553 CDD:289699 5/17 (29%)
EGF_3 1559..1595 CDD:289699 8/35 (23%)
Fasciclin 1617..1726 CDD:280607 38/129 (29%)
Fasciclin 1752..1882 CDD:280607 31/103 (30%)
EGF_3 2086..2121 CDD:289699
EGF_3 2127..2164 CDD:289699
Link_domain_TSG_6_like 2198..2290 CDD:239592
FAS1 2356..2449 CDD:214719
Interaction with TMSB4X. /evidence=ECO:0000269|PubMed:18519035 2504..2514
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2512..2551
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I11021
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1830
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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