DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mfas and Postn

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001355607.1	Gene:	Postn / 50706	MGIID:	1926321	Length:	838	Species:	Mus musculus

Alignment Length:	706	Identity:	155/706 - (21%)
Similarity:	270/706 - (38%)	Gaps:	142/706 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTK 263
            :|||||..::                                :.|..:...:||.......:|
Mouse    41 QGPNVCALQQ--------------------------------ILGTKKKYFSSCKNWYQGAIC-- 71

  Fly   264 IVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEKIDIKDVEATASDMGA---KQFLESARTAGE 325
                 |||.|:..  :||.||.|............||  .|..|...:||   :.:.:.::...|
Mouse    72 -----GKKTTVLY--ECCPGYMRMEGMKGCPAVMPID--HVYGTLGIVGATTTQHYSDVSKLREE 127

  Fly   326 LADMLGAGSGKKVTLFVPNDAAFMEY-----RGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQL 385
            :.   |.||   .|.|.|::.|:...     ||   .||||......|       ||:
Mouse   128 IE---GKGS---YTYFAPSNEAWENLDSDIRRG---LENNVNVELLNA-------LHS------- 169

  Fly   386 EDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRF-----AANCVPIEKHDKLSEQALVHTLGG 445
             .:.|:::|..:|....:..:.|.   .|||....:     ..||..:...::::...:||.:..
Mouse   170 -HMVNKRMLTKDLKHGMVIPSMYN---NLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDR 230

  Fly   446 VLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPHLRRALKEG 510
            ||..:..::.|.:....|:|..|.....::|...|..|...|:|.||:.||:||...:...:...
Mouse   231 VLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGD 295

  Fly   511 RGCASNILKNHLLDLTFCSLATVPGA--KTTAYNLL-----GEPLLLNRTHRAANQTGPTPIYIN 568
            :..:..::|.|:|:...||.|...||  :|...|.:     |:                 .|.||
Mouse   296 KVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGD-----------------SISIN 343

  Fly   569 NLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTI 633
            .:..:...||:..|||:|:||.:|..:||..:..| :.|..|.|..|:...|...........|:
Mouse   344 GIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIEL-AGKQQTTFTDLVAQLGLASSLKPDGEYTL 407

  Fly   634 FAPTDKALQNTEWARMLKEQPELLNHNLDLLE-FLNYHVVKPMIKTCDL-SEKSLPTVAGSSVRL 696
            .||.:.|..:           :.|:.:..||: .|..|::|..:...|| :.:.|.|:.|..:|:
Mouse   408 LAPVNNAFSD-----------DTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRV 461

  Fly   697 NLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPNYSKFLEL 761
            .:|.|.....:       :|  :|....:.....:|.....:.|.:.::...|..:..:|.||.|
Mouse   462 FVYRTAICIEN-------SC--MVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSL 517

  Fly   762 VRKANLTQLLSNDSRSLTLLVPKNDIFEELNESGEGSKPADPMAL---VKTHIVEDVVCCAGIIP 823
            :..|:|..||:... ..||..|.||.|:.:..........|..||   :..|:...|....|..|
Mouse   518 LEAADLKDLLTQPG-DWTLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEP 581

  Fly   824 --TNWPFVRSIESISGQHLRITRDRRPKIENAGVTK-CDVVATNGILHEINDIIVP 876
              ||     .:::..|..:.:.......:.|...:| .|::.|||::|.::.::.|
Mouse   582 GVTN-----ILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYP 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	26/120 (22%)
		Fasciclin	462..592	CDD:280607	36/136 (26%)
		Fasciclin	607..740	CDD:280607	26/134 (19%)
		Fasciclin	753..875	CDD:280607	31/127 (24%)
Postn	NP_001355607.1	Fasciclin	111..232	CDD:308211	30/147 (20%)
		Fasciclin	247..369	CDD:308211	37/138 (27%)
		Fasciclin	384..496	CDD:308211	25/131 (19%)
		Fasciclin	509..632	CDD:308211	31/128 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	811..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841929
Domainoid	1	1.000	54	0.196	Domainoid score	I11151
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4401
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm42947
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.650