DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mfas and postna

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_002663594.2	Gene:	postna / 378983	ZFINID:	ZDB-GENE-091113-23	Length:	1016	Species:	Danio rerio

Alignment Length:	726	Identity:	159/726 - (21%)
Similarity:	284/726 - (39%)	Gaps:	180/726 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTK 263
            :|||||..::                                :.|..:...::|.....|.:|
Zfish    39 EGPNVCALQQ--------------------------------VMGTKKKYFSTCRNWYKKSIC-- 69

  Fly   264 IVNQNGKKKTLTLTRQCCYGY-------GRPRNADFTTPCEKIDIKDVEATASDMGAKQFLESAR 321
                 |||..:..  :||.||       |.|..|...:....:|:...:.|      :|:.:.::
Zfish    70 -----GKKAIVLY--ECCPGYMKLEGKRGCPAVAPIDSVYGTLDLVKAKTT------QQYADQSK 121

  Fly   322 TAGELADMLGAGSGKKVTLFVPNDAAFMEYRGHHQQENNVEDAKAEASKPSIYKL---------- 376
            ...|:|   |.||   .|:|.|:|.|:.|.              ..|||.::..|
Zfish   122 LREEIA---GEGS---YTIFAPSDDAWEEL--------------DPASKAAVISLGNTELYNALH 166

  Fly   377 -HAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPIEKHDKLSEQALV 440
             |.|......:|:.|:..|::....|.:.||.|.....        ..||..|...::::...:|
Zfish   167 YHMVSKRFLTKDLKNDMTLESMFNKQGLHINHYSNGVV--------TVNCARIIHGNQVATNGVV 223

  Fly   441 HTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPHLRR 505
            |.:..|:..:::.:.|:|....|:|.:..|:...:|...|.:....|:|.||:.||||:......
Zfish   224 HVIDRVISVVSQTIKDVIETNDDLSSLSGVVVSADLQDQLGEPGHYTLFAPTNEAFDKINADALE 288

  Fly   506 ALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNLL----------GEPLLLNRTHRAANQT 560
            .|...:.....:||.|||:...||.|.:.|   :.|..|          ||.|.
Zfish   289 RLMSDQTVIQALLKYHLLNSVQCSEAIMAG---SIYGTLEGSNIEIGCDGESLT----------- 339

  Fly   561 GPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQF 625
                  :|.:..::..||:.:|||:|:||.:|..:||..:..|:. |:.::|..::...|.....
Zfish   340 ------VNGIKMVLKKDIVTSNGVIHLIDQVLMPDSAKQVMELVG-KSQSVFSDMVSELGLSAAL 397

  Fly   626 DDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLE-FLNYHVVKPMIKTCDL-SEKSLPT 688
            ......|:.||.:.|..:           |:::.:..||: .|..|:||..:...|| :.:.|.|
Zfish   398 QPETEYTVLAPLNGAFSD-----------EVMSMDQRLLKIILENHIVKLKVSLRDLYNGQLLET 451

  Fly   689 VAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANP 753
            :.|..:|:.:|.|         ...:..|.:|....|.....||.:...:..|:..:.:||..:.
Zfish   452 LGGKMLRVFIYRT---------AVCIENACMVRGSREGSNGALHLMSSLIQMPETTIYELLLKDG 507

  Fly   754 NYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFEELNESGEGSKPADPMALVKTHIVEDVVCC 818
            .:..||.|:..|.||.||..|. |.||..|.:..|        ||...|.:||:|:.|
Zfish   508 RFKIFLSLMESAGLTDLLKQDG-SYTLFAPIDAAF--------GSLTKDDLALLKSDI------- 556

  Fly   819 AGIIPT-------NWPFVRS---------IESISGQHLRI-TRDRRPKIENAGVTKCDVVATNGI 866
             .::.|       |..|:..         :::|.|.:|:: :.:....:.:..|...|::|:||:
Zfish   557 -NVLRTILLYHFSNGIFINGGLEGGVTNLLKTIQGNNLQVLSVNSSIHVNSVDVPDFDLMASNGV 620

  Fly   867 LHEINDIIVPR 877
            :|.:..::.|:
Zfish   621 VHVVKTLLYPQ 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	25/121 (21%)
		Fasciclin	462..592	CDD:280607	37/139 (27%)
		Fasciclin	607..740	CDD:280607	27/134 (20%)
		Fasciclin	753..875	CDD:280607	33/138 (24%)
postna	XP_002663594.2	Fasciclin	111..230	CDD:280607	31/152 (20%)
		Fasciclin	245..367	CDD:280607	38/141 (27%)
		Fasciclin	382..492	CDD:280607	26/129 (20%)
		FAS1	461..635	CDD:225214	44/197 (22%)
		Fasciclin	507..630	CDD:280607	33/139 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586365
Domainoid	1	1.000	48	1.000	Domainoid score	I11919
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4354
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm24964
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.660