DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mfas and Postn

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_006232397.1	Gene:	Postn / 361945	RGDID:	1305285	Length:	838	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	155/701 - (22%)
Similarity:	275/701 - (39%)	Gaps:	132/701 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTK 263
            :|||||..::                                :.|..:...:||.......:|
  Rat    41 QGPNVCALQQ--------------------------------ILGTKKKYFSSCKNWYQGAIC-- 71

  Fly   264 IVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEKIDIKDVEATASDMGA---KQFLESARTAGE 325
                 |||.|:..  :||.||.|............||  .|..|...:||   :.:.:.::...|
  Rat    72 -----GKKTTVLY--ECCPGYMRMEGMKGCPAVMPID--HVYGTLGIVGATTTQHYSDVSKLREE 127

  Fly   326 LADMLGAGSGKKVTLFVPNDAAF----MEYRGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQLE 386
            :.   |.||   .|.|.|::.|:    .:.|...:...|||...|..|       |.|...:..:
  Rat   128 IE---GKGS---YTYFAPSNEAWDNLDSDIRRGLENNVNVELLNALHS-------HMVNKRMLTK 179

  Fly   387 DVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPIEKHDKLSEQALVHTLGGVLKPLT 451
            |:.:..::.:...:..:.||.|  |..:      ...||..:...::::...:||.:..||..:.
  Rat   180 DLKHGMVIPSMYNNLGLFINHY--PNGV------VTVNCARVIHGNQIATNGVVHVIDRVLTQIG 236

  Fly   452 KNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPHLRRALKEGRGCASN 516
            .::.|.|....::|..|.....::|...|..|...|:|.||:.||:||...:...:...:..:..
  Rat   237 TSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEA 301

  Fly   517 ILKNHLLDLTFCSLATVPGA--KTTAYNLL-----GEPLLLNRTHRAANQTGPTPIYINNLAKII 574
            ::|.|:|:...||.|...||  :|...|.:     |:                 .|.||.:..:.
  Rat   302 LMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGD-----------------SISINGIKMVN 349

  Fly   575 DADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTIFAPTDK 639
            ..||:..|||:|:||.:|..:||..:..| :.|..|.|..|:...|...........|:.||.:.
  Rat   350 KKDIVTKNGVIHLIDEVLIPDSAKQVIEL-AGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNN 413

  Fly   640 ALQNTEWARMLKEQPELLNHNLDLLE-FLNYHVVKPMIKTCDL-SEKSLPTVAGSSVRLNLYSTH 702
            |..:           :.|:.:..||: .|..|::|..:...|| :.:.|.|:.|..:|:.:|.|.
  Rat   414 AFSD-----------DTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTA 467

  Fly   703 ALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPNYSKFLELVRKANL 767
            ....:       :|  :|....:.....:|.....:.|.:.::.:.|..:..:|.||.|:..|:|
  Rat   468 ICIEN-------SC--MVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADL 523

  Fly   768 TQLLSNDSRSLTLLVPKNDIFEEL-NESGE---GSKPADPMALVKTHIVEDVVCCAGIIP--TNW 826
            ..||:... ..||..|.||.|:.: ||..|   |.|.| ...::..|:...|....|..|  ||
  Rat   524 KDLLTQPG-DWTLFAPTNDAFKGMTNEEREILIGDKNA-LQNIILYHLTPGVYIGKGFEPGVTN- 585

  Fly   827 PFVRSIESISGQHLRITRDRRPKIENAGVTK-CDVVATNGILHEINDIIVP 876
                .:::..|..:.:.......:.|...:| .|::.|||::|.::.::.|
  Rat   586 ----ILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYP 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	23/114 (20%)
		Fasciclin	462..592	CDD:280607	35/136 (26%)
		Fasciclin	607..740	CDD:280607	26/134 (19%)
		Fasciclin	753..875	CDD:280607	34/128 (27%)
Postn	XP_006232397.1	Fasciclin	111..232	CDD:396845	27/141 (19%)
		Fasciclin	247..369	CDD:396845	36/138 (26%)
		Fasciclin	384..496	CDD:396845	25/131 (19%)
		Fasciclin	509..632	CDD:396845	34/129 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm45015
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.700