DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfas and tgfbi

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_878282.1	Gene:	tgfbi / 321421	ZFINID:	ZDB-GENE-030131-73	Length:	677	Species:	Danio rerio

Alignment Length:	730	Identity:	169/730 - (23%)
Similarity:	296/730 - (40%)	Gaps:	158/730 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 AAQEPW------------WKGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQ 244
            ||:.|:            .:|||||..::..                |.::...||
Zfish    19 AAKSPYQAVLQHSRIRGRTQGPNVCAMQKIP----------------GSDKKYFTN--------- 58

  Fly   245 FQFSVNSCAEKPNKHVCTKIVNQNGKKKTLTLTRQCCYGYGR---PRNADFTTPCEKI--DIKDV 304
                   |.:...:.:|         .|...::.:||.||.:   .:......|...|  .:..|
Zfish    59 -------CKQWYRRKIC---------GKPTVISYECCPGYEKVIGEKGCPAALPLVNIYKTLSVV 107

  Fly   305 EATASDMGAKQFLESARTAGELADMLGAGSGKKVTLFVPNDAAFMEYRGHHQQENNVEDAKAEAS 369
            |||.:    |.:.|.|:...|:.   |.||   .|.|.|::.|:...        ..|...|..|
Zfish   108 EATTT----KMYSERAKLQEEIE---GPGS---FTFFAPSNEAWAPL--------PTEILDALVS 154

  Fly   370 KPSIYKL-----HAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPIE 429
            ..:|..|     |.:...:..||:.:.....:...|..:.|:.|    :.|:    ...||..:.
Zfish   155 NVNIELLNALHYHMINKRLTSEDLKHGSSFSSMHQDFDVHIHHY----SNGI----VTVNCARLV 211

  Fly   430 KHDKLSEQALVHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDA 494
            |.|:.:...:||.:..|:..:|.::..||....|:..:||.:....|:.:||:....|||.||:.
Zfish   212 KTDQHATNGIVHVVDRVITAITNDVNSIIDTDDDLDTLRTAVAAAGLTTLLENQGSYTIFAPTNE 276

  Fly   495 AFDKLEPH-LRR------ALKEGRGCASNILKNHLLDLTFCSLATVPGA--KTTAYNLL-----G 545
            ||:|:.|. |.|      |||:       :|..|:|....||.:.|.|.  :|....:|     |
Zfish   277 AFEKIPPDTLTRILGDPVALKD-------LLNFHILKNLHCSESIVAGTPLETLQGTMLEVGCDG 334

  Fly   546 EPLLLNRTHRAANQTGPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLT 610
            |.|.                 ||..|.:...|.:|||||:|.|:.:|..:||..:..|.....:|
Zfish   335 EDLT-----------------INGKAVVTQKDKLGTNGVVHYINELLIPDSAKTLLELAEGSVVT 382

  Fly   611 IFQRLLEASGYDDQFDDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPM 675
            ...:|.:.:|.:|.....::||:.||.::|.::..:|.           ..|:.:.|..|::|..
Zfish   383 TAAKLFKDAGLNDHLVGSESVTLLAPLNEAFKDKSFAM-----------TPDMKKLLRNHILKEK 436

  Fly   676 IKTCDLSE-KSLPTVAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALA 739
            ..:..|.. :.|.|:.|..:|:.::         .|...:..|.:...|.....:.:..||..|.
Zfish   437 FSSKSLYHGQELETLGGLKLRVFVF---------RNNLCIENACIAAHDKNGRYANMFLVDSILT 492

  Fly   740 PPKNNMLKLLEANPNYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFEELNESGEGSKPADPM 804
            ||:..::.:|:|:..:|..:..::||.||:|| |...:.|...|.|..|..|..:.......||.
Zfish   493 PPQGTVMDVLKADNRFSTLVGAIQKAGLTELL-NKKGTYTFFAPTNAAFSALPSADLNKLMRDPK 556

  Fly   805 AL---VKTHIVEDVVCCAGIIPTNWPFVRSIESISGQHLRI-TRDRRPKIENAGVTKCDVVATNG 865
            .|   :|.||.::.: .:|.:.::    ..::.::|..|.: ||:....:....|.:.|::||||
Zfish   557 ELANILKYHIGDEFL-VSGAVTSH----TRLKPLAGDKLELGTRNSTIYVNRVPVVESDLMATNG 616

  Fly   866 ILHEINDIIVPRPQR 880
            ::|.:|.||.|.|.:
Zfish   617 VVHAVNVIIKPLPPK 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	23/115 (20%)
		Fasciclin	462..592	CDD:280607	43/143 (30%)
		Fasciclin	607..740	CDD:280607	25/133 (19%)
		Fasciclin	753..875	CDD:280607	33/125 (26%)
tgfbi	NP_878282.1	Fasciclin	110..229	CDD:280607	30/144 (21%)
		Fasciclin	250..366	CDD:280607	43/139 (31%)
		Fasciclin	382..493	CDD:280607	25/130 (19%)
		Fasciclin	507..627	CDD:280607	34/125 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586363
Domainoid	1	1.000	48	1.000	Domainoid score	I11919
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37294
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4354
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm24964
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1830
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.730