DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfas and SPAC22H12.05c

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_593117.1	Gene:	SPAC22H12.05c / 2541828	PomBaseID:	SPAC22H12.05c	Length:	728	Species:	Schizosaccharomyces pombe

Alignment Length:	393	Identity:	80/393 - (20%)
Similarity:	155/393 - (39%)	Gaps:	106/393 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 NLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAF--DKLEPHLRRALKEGRGCAS 515
            :::|::..::..|.:...|::..|...|..:|.:|:|.|.:.||  |.:||:|...:........
pombe    31 SIIDLLSSKSQFSKLIRRLQRNRLVPYLNRNKGLTLFAPLNEAFPDDSIEPNLLYYIVNTTELDR 95

  Fly   516 NILKNHLLDLTFCSLATVPGAKTTAYNLLGEPLLLNRTHRAANQTGPTPIYINNLAKIIDADIMG 580
            ::|:..|              |::.    |:.:.|...::|  :||.....:|| |:|:.::...
pombe    96 SVLRTQL--------------KSSD----GQQIALKIHYKA--ETGRAYDKVNN-AQIVQSNWRA 139

  Fly   581 TNGVLHVIDTILPTESALP---MTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTIFAPTDKAL- 641
            .:||:.|||.|:.    ||   :..|.|:|:.:||.||..|     ...:..:||:..|...|.
pombe   140 DSGVVQVIDNIID----LPPPALEILSSEKDFSIFHRLSVA-----WVGEYSSVTMLVPDSSAFL 195

  Fly   642 ---QNTEWA-----------RMLKEQPELLNHNL---DLLEFLNYHVVKPMIKTCDLSEKSLPTV 689
               .|||.|           :.|..|..|:|..:   |::|...:|...
pombe   196 NVYTNTELAYLYSMYAAEDVKTLIHQHILVNQRVYAEDVIEPKTFHYKN---------------- 244

  Fly   690 AGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPN 754
             |.|:.:.       |.....:..:|......:|..:....:|.|...:.|      :::...|
pombe   245 -GISISMK-------FDKDQKKLFINDVSTTKYDLLTFSGAIHTVSSLINP------EIISFTP- 294

  Fly   755 YSKFLELVRKANLTQLLSNDSRSLT--------LLVPKNDIFEELNESGEGSKPADPMALVKTHI 811
             :|:|..:..|..::.||.:.:|::        :|.|.|..:.|:.:             :..||
pombe   295 -AKYLIGIGAAWFSEKLSRERKSISVDKTSKRAILAPTNWAYREIID-------------IDYHI 345

  Fly   812 VED 814
            :|:
pombe   346 IEN 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719
		Fasciclin	462..592	CDD:280607	31/131 (24%)
		Fasciclin	607..740	CDD:280607	28/150 (19%)
		Fasciclin	753..875	CDD:280607	14/70 (20%)
SPAC22H12.05c	NP_593117.1	Fasciclin	40..151	CDD:280607	31/131 (24%)
		FAS1	78..422	CDD:225214	68/346 (20%)
		Fasciclin	179..287	CDD:295423	22/131 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1830
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840