DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mfas and Tgfbi

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_033395.1	Gene:	Tgfbi / 21810	MGIID:	99959	Length:	683	Species:	Mus musculus

Alignment Length:	730	Identity:	164/730 - (22%)
Similarity:	302/730 - (41%)	Gaps:	139/730 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 GAAQEPW------------WKGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFG 243
            |.|:.|:            ..|||||..::                ..|..:...||
Mouse    24 GPAKSPYQLVLQHSRLRGRQHGPNVCAVQK----------------VIGTNKKYFTN-------- 64

  Fly   244 QFQFSVNSCAEKPNKHVCTKIVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEK-----IDIKD 303
                    |.:...:.:|         .|:..::.:||.||.:       .|.||     :.:.:
Mouse    65 --------CKQWYQRKIC---------GKSTVISYECCPGYEK-------VPGEKGCPAALPLSN 105

  Fly   304 VEATASDMGAKQF-LESARTAGELADMLGAGSGKKVTLFVPNDAAF----MEYRGHHQQENNVED 363
            :..|...:|:... |.:.||.....:|.|.||   .|:|.|::.|:    .|.........|:|.
Mouse   106 LYETMGVVGSTTTQLYTDRTEKLRPEMEGPGS---FTIFAPSNEAWSSLPAEVLDSLVSNVNIEL 167

  Fly   364 AKAEASKPSIYKLHAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPI 428
            ..|       .:.|.|...|..:::.:...|.:...:..|:|:.|  |..:      ...||..:
Mouse   168 LNA-------LRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHY--PNGI------VTVNCARL 217

  Fly   429 EKHDKLSEQALVHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTD 493
            .|.|..:...:||.:..|:..:|.|:..||........:|..:..:.|:.:||.|...|:..||:
Mouse   218 LKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFTLLAPTN 282

  Fly   494 AAFDKLEPH-LRRALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNLLGEPLLLNRTHRAA 557
            .||:|:... |.|.|.:.. ...::|.||:|....|:.|.|.|   .:...||...|
Mouse   283 EAFEKIPAETLNRILGDPE-ALRDLLNNHILKSAMCAEAIVAG---MSMETLGGTTL-------- 335

  Fly   558 NQTGPT--PIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASG 620
             :.|.:  .:.||..|.|.:.||:.||||:|.||.:|..:||..:..|..:.:::....:|:.:|
Mouse   336 -EVGCSGDKLTINGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTAIDILKQAG 399

  Fly   621 YDDQFDDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPMIKTCDL-SEK 684
            .|......:.:|..||.:.         :.|:....::..:..| .|| |:||..:.:..| |.:
Mouse   400 LDTHLSGKEQLTFLAPLNS---------VFKDGVPRIDAQMKTL-LLN-HMVKEQLASKYLYSGQ 453

  Fly   685 SLPTVAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLL 749
            :|.|:.|..:|:.:|         .|...:..:.:...|.......|..:||.|.||...::.:|
Mouse   454 TLDTLGGKKLRVFVY---------RNSLCIENSCIAAHDKRGRFGTLFTMDRMLTPPMGTVMDVL 509

  Fly   750 EANPNYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIF-----EELNESGEGSKPADPMALVKT 809
            :.:..:|..:..::.|.|.::|:.:. ..|:..|.|:.|     ||||:....:|  :...::|.
Mouse   510 KGDNRFSMLVAAIQSAGLMEILNREG-VYTVFAPTNEAFQAMPPEELNKLLANAK--ELTNILKY 571

  Fly   810 HIVEDVVCCAGIIPTNWPFVRSIESISGQHLRI-TRDRRPKIENAGVTKCDVVATNGILHEINDI 873
            ||.::::...||    ...|| ::|:.|..|.: :::....:....|.:.|::||||:::.||.:
Mouse   572 HIGDEILVSGGI----GALVR-LKSLQGDKLEVSSKNNVVSVNKEPVAETDIMATNGVVYAINTV 631

  Fly   874 IVPRPQRQQQQRPQL 888
            :.|...|.|::..:|
Mouse   632 LQPPANRPQERGDEL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	23/114 (20%)
		Fasciclin	462..592	CDD:280607	39/132 (30%)
		Fasciclin	607..740	CDD:280607	26/133 (20%)
		Fasciclin	753..875	CDD:280607	31/127 (24%)
Tgfbi	NP_033395.1	Fasciclin	133..236	CDD:280607	25/120 (21%)
		Fasciclin	253..373	CDD:280607	40/132 (30%)
		Fasciclin	386..500	CDD:280607	26/133 (20%)
		Fasciclin	514..634	CDD:280607	31/127 (24%)
		Cell attachment site. /evidence=ECO:0000255	642..644		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841928
Domainoid	1	1.000	54	0.196	Domainoid score	I11151
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37294
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4401
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm42947
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1830
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.690