DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mfas and Tgfbi

DIOPT Version :9

Sequence 1:	NP_788655.1	Gene:	mfas / 41455	FlyBaseID:	FBgn0260745	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_446254.1	Gene:	Tgfbi / 116487	RGDID:	620017	Length:	685	Species:	Rattus norvegicus

Alignment Length:	696	Identity:	163/696 - (23%)
Similarity:	297/696 - (42%)	Gaps:	105/696 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 GVTNVVRSPLFGQFQFSVNSCAEKPNKH---VCT--KIVNQNGK--------------KKTLTLT 277
            |.|..:..|....:|..:.....:..:|   ||.  |::..|.|              .|:..::
  Rat    17 GFTGTLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVIS 81

  Fly   278 RQCCYGYGRPRNADFTTPCEK-----IDIKDVEATASDMGAKQF-LESARTAGELADMLGAGSGK 336
            .:||.||.:       .|.||     :.:.::..|...:|:... |.:.||.....:|.|.||
  Rat    82 YECCPGYEK-------VPGEKGCPAALPLSNLYETLGIVGSTTTQLYTDRTEKLRPEMEGPGS-- 137

  Fly   337 KVTLFVPNDAAF----MEYRGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQLEDVPNEKLLQTE 397
             .|:|.|::.|:    .|.........|:|...|       .:.|.|...|..:::.:...|.:.
  Rat   138 -FTIFAPSNEAWSSLPAEVLDSLVSNVNIELLNA-------LRYHMVDRRVLTDELKHGMALTSM 194

  Fly   398 LPDQKIRINSYQLPAALGLEPYRFAANCVPIEKHDKLSEQALVHTLGGVLKPLTKNLMDIIRERA 462
            ..:..|:|:.|  |..:      ...||..:.|.|..:...:||.:..|:..:|.|:..||....
  Rat   195 YQNSNIQIHHY--PNGI------VTVNCARLLKADHHATNGVVHLIDKVISTVTNNIQQIIEIED 251

  Fly   463 DMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPH-LRRALKEGRGCASNILKNHLLDLT 526
            ....:|..:..:.|:.:||.|...|:..||:.||:|:... |.|.|.:.. ...::|.||:|...
  Rat   252 TFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEKIPAETLNRILGDPE-ALRDLLNNHILKTA 315

  Fly   527 FCSLATVPGAKTTAYNLLGEPLLLNRTHRAANQTGPT--PIYINNLAKIIDADIMGTNGVLHVID 589
            .|:.|.|.|   .|...||...|         :.|.:  .:.||..|.|.:.||:.||||:|.||
  Rat   316 MCAEAIVAG---MAMETLGGTTL---------EVGCSGDMLTINGKAVISNKDILATNGVIHFID 368

  Fly   590 TILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTIFAPTDKALQNTEWARMLKEQP 654
            .:|..:||..:..|.|:.:::....||..:|........:.:|..||.:.         :.|:..
  Rat   369 ELLIPDSAKTLLELASESDVSTAIDLLRQAGLSTHLSGKEQLTFLAPLNS---------VFKDGV 424

  Fly   655 ELLNHNLDLLEFLNYHVVKPMIKTCDL-SEKSLPTVAGSSVRLNLYSTHALFSDVMNRATVNCAR 718
            ..::..:..| .|| |:||..:.:..| |.::|.|:.|..:|:.:|         .|...:..:.
  Rat   425 PRIDGQMKTL-LLN-HMVKGQLASKYLYSGQTLDTLGGKKLRVFVY---------RNSLCIENSC 478

  Fly   719 LVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPNYSKFLELVRKANLTQLLSNDSRSLTLLVP 783
            :...|.:.....|..:||.|.||...::.:|:.:..:|..:..::.|.|.:.|:.:. ..|:..|
  Rat   479 IAAHDKKGRYGTLFTMDRMLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLMETLNREG-VYTVFAP 542

  Fly   784 KNDIF-----EELNESGEGSKPADPMALVKTHIVEDVVCCAGIIPTNWPFVRSIESISGQHLRI- 842
            .|:.|     ||||:....:|  :...::|.||.::::...||    ...|| ::|:.|..|.:
  Rat   543 TNEAFQAMPPEELNKLLANAK--ELTNILKYHIGDEILVSGGI----GALVR-LKSLQGDKLEVS 600

  Fly   843 TRDRRPKIENAGVTKCDVVATNGILHEINDIIVPRPQRQQQQRPQL 888
            :::....:....|.:.|::||||:::.||.::.|...|.|::..:|
  Rat   601 SKNNVVSVNKEPVAETDIMATNGVVYAINTVLQPPANRPQERGEEL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mfas	NP_788655.1	FAS1	339..450	CDD:214719	23/114 (20%)
		Fasciclin	462..592	CDD:280607	40/132 (30%)
		Fasciclin	607..740	CDD:280607	26/133 (20%)
		Fasciclin	753..875	CDD:280607	31/127 (24%)
Tgfbi	NP_446254.1	Fasciclin	133..236	CDD:280607	25/120 (21%)
		Fasciclin	253..373	CDD:280607	41/132 (31%)
		Fasciclin	386..500	CDD:280607	26/133 (20%)
		Fasciclin	514..634	CDD:280607	31/127 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37294
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4345
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395206at33208
OrthoFinder	1	1.000	-	-		FOG0002089
OrthoInspector	1	1.000	-	-		otm45015
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.660