DRSC/TRiP Functional Genomics Resources

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Protein Alignment mfas and Stab1

DIOPT Version :10

Sequence 1:NP_788655.1 Gene:mfas / 41455 FlyBaseID:FBgn0260745 Length:905 Species:Drosophila melanogaster
Sequence 2:XP_008769275.1 Gene:Stab1 / 100363145 RGDID:2324745 Length:2630 Species:Rattus norvegicus


Alignment Length:488 Identity:106/488 - (21%)
Similarity:161/488 - (32%) Gaps:158/488 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   415 GLEPYRFAANCVPIEKHDKLSEQALVHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAM 479
            |..||   |.|.......:.......||:|..:....:..::::|.:........:||...    
  Rat  1610 GCSPY---AVCKSTGDGQRTCSCDSTHTVGDGITCHGRVGLELLRNKYASFFSLHLLEYKE---- 1667

  Fly   480 LEDDKPVTIFVP-TDAAFDKLEPHLRRALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNL 543
            |:.|.|.||||| :|...:..:..|.|.    |.....:.:.|:|.   |       .|..:..|
  Rat  1668 LKGDGPFTIFVPHSDLISNMSQGELARM----RAHRQLVFRYHVLG---C-------RKLGSQEL 1718

  Fly   544 LGE---PLLLNRTHRAANQTGPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPM---TS 602
            |.:   ..|...|.|.:.:.|  .||:|:.|:::.:|....|||||.||.:|.....|..   |.
  Rat  1719 LDQGYVTALSGHTLRISEREG--SIYLNDFARVVSSDHEAVNGVLHFIDRVLLPPDVLHWEADTI 1781

  Fly   603 LMSQKNLT---------IFQRLLEASGYDDQFDDLDN--VTIFAPTDKALQNTEWARMLKEQPEL 656
            .:.::|:|         ||.|||..:|......|..:  .|:..|||.||:..        .|:.
  Rat  1782 PIPRRNVTAAAESFQYKIFSRLLTVAGLLPMLQDASHRPFTMLWPTDSALEAL--------SPDR 1838

  Fly   657 LN------HNLDLLEFLNYHVVKPMIKTCDLSEKSLPTVAGSSVRLNLYSTHALFSDVMNRATVN 715
            .|      |...|...|..||    |:..:.|...||.:.      .|.:.|.      |..:.:
  Rat  1839 KNWLYHEDHRDKLAAILRGHV----IRNIEASASDLPNLG------QLRTMHG------NTISFS 1887

  Fly   716 C--------------ARLVH----FDDESCGSVLHQVDRALAPP--------------KNNMLKL 748
            |              ||:|.    |:    |.:.:.:|:.|.||              :.....:
  Rat  1888 CGLARPGELMVGENEARIVQRYLLFE----GGLAYGIDQLLEPPDLGARCDRFEPQPLQTKTCSI 1948

  Fly   749 LEANP-----------------NYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFEELNESGE 796
            ....|                 :||||.       .|.|.|...|..:.:.|.   |...|..|.
  Rat  1949 CGLEPPCPRGSREQGSPEACWRHYSKFW-------ATPLHSITMRGGSWITPS---FWNRNHMGR 2003

  Fly   797 GS---------KPADPMALVKTHIVEDVVCCAG 820
            |.         ||:               ||.|
  Rat  2004 GCHRKCVTTVWKPS---------------CCPG 2021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mfasNP_788655.1 FAS1 339..450 CDD:214719 8/34 (24%)
Fasciclin 462..592 CDD:396845 36/133 (27%)
Fasciclin 607..740 CDD:396845 37/167 (22%)
Fasciclin 753..875 CDD:396845 19/94 (20%)
Stab1XP_008769275.1 FAS1 502..647 CDD:441906
EGF_3 834..863 CDD:463759
EGF_3 918..949 CDD:463759
EGF_3 955..991 CDD:463759
Fasciclin <1100..1180 CDD:396845
Fasciclin 1224..1313 CDD:470649
EGF_3 1519..1555 CDD:463759
EGF_3 1561..1595 CDD:463759
EGF_3 1604..1641 CDD:463759 8/33 (24%)
Fasciclin 1666..1770 CDD:396845 35/123 (28%)
Fasciclin 1796..1926 CDD:396845 35/157 (22%)
EGF_Lam 2037..2082 CDD:238012
EGF_3 2154..2189 CDD:463759
EGF_3 2195..2232 CDD:463759
Link_Domain 2267..2359 CDD:470631
FAS1 2426..2521 CDD:214719
Fasciclin 391..494 CDD:470649
Blue background indicates that the domain is not in the aligned region.

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