Protein Alignment CG12224 and AKR1C3

DIOPT Version :9

• Sequence 1: NP_650139.3
• Gene: CG12224 / 41453
• FlyBaseID: FBgn0037974
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_001240837.1
• Gene: AKR1C3 / 8644
• HGNCID: 386
• Length: 323
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 72/314 - (22%)
• Similarity: 134/314 - (42%)
• Gaps: 69/314 - (21%)

  Fly    54 REEGILMVQEAIRSGINYIDTAP-FLSEVLLGQALK------DVPREAYYIATKVARYGLDPKNM 111
            |.:.:.:.:.||.:|..:||:|. :.:|..:|.|::      .|.||..:..:|:       .:.
Human    31 RSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKL-------WST 88

  Fly   112 FDYSADKARESVKRSLERLQLDRVDILQVH--------------DVDAAPNLDIV-LNETIPVLE 161
            | :..:..|.:::.||::.|||.||:..:|              |.:.....||| |..|...:|
Human    89 F-HRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAME 152

  Fly   162 EYVQAGKARFIGVTAYDVDVLKECAERGKGRIQVVLNY--ARYTLLDNTLLRY-------MKDFQ 217
            :...||.|:.|||:.::           :.:::::||.  .:|..:.|.:..:       :.||.
Human   153 KCKDAGLAKSIGVSNFN-----------RRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFC 206

  Fly   218 KMGVGVVCAAAHSLGLLRNAGPHASHPGSQEIL------AVAKRGAEICQQRNVELGKLAMYYTM 276
            | ...:|..|..:||..|:  .....|.|..:|      |:||:     .:|...|  :|:.|
Human   207 K-SKDIVLVAYSALGSQRD--KRWVDPNSPVLLEDPVLCALAKK-----HKRTPAL--IALRY-- 259

  Fly   277 QLDGAATFLIGIPNRKLLRINLDAIFDGLTSHEQEVLQYLRENV-FTKSYSWGS 329
            ||......|....|.:.:|.|:......||:.:.:.:..|..|: :..|.|:.|
Human   260 QLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFAS 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.3	AKR_galDH	22..311	CDD:381389	67/293 (23%)
AKR1C3	NP_001240837.1	ARA1	9..305	CDD:223729	69/304 (23%)
		Tas	17..297	CDD:223739	67/296 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910