Protein Alignment CG12224 and KCNAB2

DIOPT Version :10

• Sequence 1: NP_650139.4
• Gene: CG12224 / 41453
• FlyBaseID: FBgn0037974
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_001186791.1
• Gene: KCNAB2 / 8514
• HGNCID: 6229
• Length: 415
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 91/367 - (24%)
• Similarity: 155/367 - (42%)
• Gaps: 87/367 - (23%)

  Fly    22 MEYRQLGSTGLHVSKLAIG-----GSPLCNLFFDDYDREEGILMVQEAIRSGINYIDTAPFY--G 79
            |:||.||.:||.||.|.:|     |..:.:      :..|.::.:  |..:|||..|||..|  |
Human    70 MKYRNLGKSGLRVSCLGLGTWVTFGGQITD------EMAEQLMTL--AYDNGINLFDTAEVYAAG 126

  Fly    80 QSEVLLGQALKDV--PREAYYIATKV-------ARYGLDPKNMFDYSADKARESVKRSLERLQLD 135
            ::||:||..:|..  .|.:..|.||:       ...||..|::.        |.:|.|||||||:
Human   127 KAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHII--------EGLKASLERLQLE 183

  Fly   136 RVDILQVHDVDAAPNLDI-------------VLNETIPVLEEYVQAGKARFIGVTAYDVDVLKEC 187
            .||::..:..|  ||..:             ::.||:..:...:..|.|.:.|.:.:....:.|.
Human   184 YVDVVFANRPD--PNTPMEGDPFSSSKSRTFIIEETVRAMTHVINQGMAMYWGTSRWSSMEIMEA 246

  Fly   188 --AERGKGRIQVVLNYARYTLL--DNTLLRYMKDFQKMGVGVVCAAAHSLGLLR---NAG--PH- 242
              ..|.......:...|.|.:.  :...::..:.|.|:|||.:..:..:.|::.   ::|  |:
Human   247 YSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYS 311

  Fly   243 -ASHPGSQ----EIL--------AVAKRGAEICQQRNVELGKLAMYYTMQLDGAATFLIGIPNRK 294
             ||..|.|    :||        |..|....|.::....|.:||:.:.::.:|.::.|:|..|..
Human   312 RASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAD 376

  Fly   295 LLRINLDAIFDGLTSHEQEVLQYLRENVF--------TKSYS 328
            .|..|:.||         :||..|..::.        .|.||
Human   377 QLMENIGAI---------QVLPKLSSSIIHEIDSILGNKPYS 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.4	AKR_galDH	22..313	CDD:381389	85/342 (25%)
KCNAB2	NP_001186791.1	Aldo_ket_red_shaker	71..395	CDD:381367	87/350 (25%)