Protein Alignment CG12224 and AAD3

DIOPT Version :10

• Sequence 1: NP_650139.4
• Gene: CG12224 / 41453
• FlyBaseID: FBgn0037974
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_010032.1
• Gene: AAD3 / 850471
• SGDID: S000000704
• Length: 363
• Species: Saccharomyces cerevisiae
• Alignment Length: 358
• Identity: 80/358 - (22%)
• Similarity: 139/358 - (38%)
• Gaps: 83/358 - (23%)

  Fly    27 LGSTGLHVSKL----------AIGGSPLC----------NLFFDDYDREEGILMVQEAIRSGINY 71
            :||.....|||          ||..|||.          :.|....::.....::.....:|.|:
Yeast     2 IGSASDSSSKLGRLRFLSETAAIKVSPLILGEVSYDGARSDFLKSMNKNRAFELLDTFYEAGGNF 66

  Fly    72 IDTAP--FYGQSEVLLGQALKDVP-REAYYIATKV----ARYGLDPKNMFDYSADKARE---SVK 126
            ||.|.  ...|||..:|:.::... |:...||||.    .:|.....|..:|..:..|.   ||:
Yeast    67 IDAANNCQNEQSEEWIGEWIQSRRLRDQIVIATKFIKSDKKYKAGESNTANYCGNHKRSLHVSVR 131

  Fly   127 RSLERLQLDRVDILQVHDVDAAPNLDIVLNETIPVLEEYVQAGKARFIGVT---AYDVDVLKECA 188
            .||.:||.|.:|||.||..|...:::    |.:..|...||.||..::||:   |:.|......|
Yeast   132 DSLRKLQTDWIDILYVHWWDYMSSIE----EFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYA 192

  Fly   189 ERGKGRIQVVLNYARYTLLDNTLLRYMKDFQKMGVGVVCAAAHSLGLL----------------- 236
             ...|:....:...::.:|:       :||::   .::..|.| .|:.
Yeast   193 -TSYGKTPFSIYQGKWNVLN-------RDFER---DIIPMARH-FGMALAPWDVMGGGRFQSKKA 245

  Fly   237 -----RNAGPHASHPGSQE----ILAVAKRGAEICQQRNVE-LGKLAMYYTMQLDGAATFLIGIP 291
                 :|.....|..|:.|    .:.:::..|:|.::...| :..:|:.|..  ..|..|...:.
Yeast   246 MEERRKNGEGIRSFVGASEQTDAEIKISEALAKIAEEHGTESVTAIAIAYVR--SKAKNFFPSVE 308

  Fly   292 NRKL--LRINLDAIFDGLTSHEQEVLQYLRENV 322
            ..|:  |:.|:.|:...||   .:.::||...|
Yeast   309 GGKIEDLKENIKALSIDLT---PDNIKYLESIV 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.4	AKR_galDH	22..313	CDD:381389	77/347 (22%)
AAD3	NP_010032.1	AKR_AKR9A3_9B1-4	17..335	CDD:381373	73/338 (22%)