DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12224 and KCNAB1

DIOPT Version :9

Sequence 1:	NP_650139.3	Gene:	CG12224 / 41453	FlyBaseID:	FBgn0037974	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_751892.1	Gene:	KCNAB1 / 7881	HGNCID:	6228	Length:	419	Species:	Homo sapiens

Alignment Length:	346	Identity:	82/346 - (23%)
Similarity:	147/346 - (42%)	Gaps:	64/346 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MEYRQLGSTGLHVSKLAIG-----GSPLCNLFFDDYDREEGILMVQEAIRSGINYIDTAPFL--- 78
            |.:|.||.:||.||.|.:|     |..:.:      :..|.::.:  |..||:|..|||...
Human    89 MPHRNLGKSGLRVSCLGLGTWVTFGGQISD------EVAERLMTI--AYESGVNLFDTAEVYAAG 145

  Fly    79 -SEVLLGQALKDV--PREAYYIATKV-------ARYGLDPKNMFDYSADKARESVKRSLERLQLD 133
             :||:||..:|..  .|.:..|.||:       ...||..|::.        |.:|.||:||||:
Human   146 KAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHII--------EGLKGSLQRLQLE 202

  Fly   134 RVDILQVHDVDAAPNLDIVLNETIPVLEEYVQAGKARFIGVTAYDVDVLKEC--AERGKGRIQVV 196
            .||::..:    .|:.:..:.|.:..:...:..|.|.:.|.:.:....:.|.  ..|....|..|
Human   203 YVDVVFAN----RPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPV 263

  Fly   197 LNYARYTLL--DNTLLRYMKDFQKMGVGVVCAAAHSLGLLR----NAGPHASHPG-------SQE 248
            ...|.|.|.  :...::..:.:.|:|||.:..:..:.|::.    |..|.:|...       .:.
Human   264 CEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 328

  Fly   249 ILAVAKRGAE--------ICQQRNVELGKLAMYYTMQLDGAATFLIGIPNRKLLRINLDAI--FD 303
            |::...|..:        |.::....|.:||:.:.::.:|.::.|:|....:.|..||.||  ..
Human   329 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLP 393

  Fly   304 GLTSH-EQEVLQYLRENVFTK 323
            .:||| ..|:...||...::|
Human   394 KMTSHVVNEIDNILRNKPYSK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.3	AKR_galDH	22..311	CDD:381389	78/332 (23%)
KCNAB1	NP_751892.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Kv_beta	91..407	CDD:213602	78/335 (23%)
		Aldo_ket_red	91..406	CDD:119408	78/334 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960