DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12224 and AKR1B10

DIOPT Version :9

Sequence 1:	NP_650139.3	Gene:	CG12224 / 41453	FlyBaseID:	FBgn0037974	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_064695.3	Gene:	AKR1B10 / 57016	HGNCID:	382	Length:	316	Species:	Homo sapiens

Alignment Length:	248	Identity:	55/248 - (22%)
Similarity:	94/248 - (37%)	Gaps:	64/248 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VQEAIRSGINYIDTA-PFLSEVLLGQAL------KDVPREAYYIATKVARYGLDPKNMFDYSADK 118
            |:.||.:|..:||.| .:.:|..:|:|:      |.|.||..:|.:|     |.|.   .:....
Human    32 VKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSK-----LWPT---FFERPL 88

  Fly   119 ARESVKRSLERLQLDRVDILQVH-------DVDAAPNLD--------IVLNETIPVLEEYVQAGK 168
            .|::.:::|:.|:|..:|:..:|       ..|..|..|        ....:....:||.|..|.
Human    89 VRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGL 153

  Fly   169 ARFIGVTAYDVDVLKECAERGKGRIQVVLNYAR---YTLLDNTLLRYMKDFQKMGVGVVCAAAHS 230
            .:.:||:.:....:::...:...:.:.|.|...   | |....|::|..     ..|:...|...
Human   154 VKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPY-LTQEKLIQYCH-----SKGITVTAYSP 212

  Fly   231 LG-------------LLRNAGPHASHPGSQEILAVAKRGA-----EICQQRNV 265
            ||             ||.:       |..:||.|..|:.|     ....||||
Human   213 LGSPDRPWAKPEDPSLLED-------PKIKEIAAKHKKTAAQVLIRFHIQRNV 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.3	AKR_galDH	22..311	CDD:381389	55/248 (22%)
AKR1B10	NP_064695.3	AKR_AKR1B1-19	10..316	CDD:381333	55/248 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910