Protein Alignment CG12224 and AKR1C4

DIOPT Version :9

• Sequence 1: NP_650139.3
• Gene: CG12224 / 41453
• FlyBaseID: FBgn0037974
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 75/308 - (24%)
• Similarity: 128/308 - (41%)
• Gaps: 78/308 - (25%)

  Fly    54 REEGILMVQEAIRSGINYIDTA-PFLSEVLLGQALK------DVPREAYYIATKVARYGLDPKNM 111
            |...:.:.:.||.:|..:||:| .:.:|..:|.|::      .|.||..:..:|:......|:
Human    31 RNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQ-- 93

  Fly   112 FDYSADKARESVKRSLERLQLDRVDILQVH--------------DVDAAPNLDIV-LNETIPVLE 161
                  ..:.:::.||::||||.||:..:|              |.:.....|.| |:.|..|:|
Human    94 ------MVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVME 152

  Fly   162 EYVQAGKARFIGVTAYDVDVLKECAERGKGRIQVVLNY--ARYTLLDNTL-----LRYMK--DFQ 217
            :...||.|:.|||:.::      |.:     ::::||.  .:|..:.|.:     |...|  ||.
Human   153 KCKDAGLAKSIGVSNFN------CRQ-----LEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFC 206

  Fly   218 KMGVGVVCAAAHSLGLLRNAGPHASH-----PGSQEIL------AVAKRGAEICQQRNVELGKLA 271
            | ...:|..|..:||..|       |     |.|..:|      |:||:     .::...|  :|
Human   207 K-SKDIVLVAHSALGTQR-------HKLWVDPNSPVLLEDPVLCALAKK-----HKQTPAL--IA 256

  Fly   272 MYYTMQLDGAATFLIGIPNRKLLRINLDAIFDGLTSHEQEVLQYLREN 319
            :.|  ||......|....|.:.:|.|:......|||.:.:||..|..|
Human   257 LRY--QLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12224	NP_650139.3	AKR_galDH	22..311	CDD:381389	71/298 (24%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	75/308 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910