DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18547 and KCNAB1

DIOPT Version :9

Sequence 1:	NP_650138.1	Gene:	CG18547 / 41452	FlyBaseID:	FBgn0037973	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_751892.1	Gene:	KCNAB1 / 7881	HGNCID:	6228	Length:	419	Species:	Homo sapiens

Alignment Length:	343	Identity:	88/343 - (25%)
Similarity:	151/343 - (44%)	Gaps:	55/343 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MEYRNLGKTGLQVS------KVSFGGGALCANYGFDLEEGIKTVHEAVKSGINYIDTAPWYGQGR 80
            |.:|||||:||:||      .|:|||     ....::.|.:.|:  |.:||:|..|||..|..|:
Human    89 MPHRNLGKSGLRVSCLGLGTWVTFGG-----QISDEVAERLMTI--AYESGVNLFDTAEVYAAGK 146

  Fly    81 SEEVLGLALKDV--PRESYYIATKV---ARYELDYDKMFDFSAKKTRESVEKSLKLLGLDYVDVI 140
            :|.:||..:|..  .|.|..|.||:   .:.|.:.    ..|.|...|.::.||:.|.|:||||:
Human   147 AEVILGSIIKKKGWRRSSLVITTKLYWGGKAETER----GLSRKHIIEGLKGSLQRLQLEYVDVV 207

  Fly   141 QIHDIEFAK--DLDIVINETLPTLEQLVKEGKARFIGVSAYPISVLKE--FLTRTAGRLDTVLTY 201
                  ||.  |.:..:.|.:..:..::.:|.|.:.|.|.:....:.|  .:.|....:..|...
Human   208 ------FANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQ 266

  Fly   202 ARYTL--TDETLLEYLDFFKSQNLGVICAAAHALGLLT----NAGPQ---------PW---HPAS 248
            |.|.|  .::..::..:.:....:|.:..:..|.|:::    |..|:         .|   ...|
Human   267 AEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVS 331

  Fly   249 DE---QKAIARKASEVCKERGVELGKLAMYYTMSGLPEVSTFLTGMQTRQLLRINLDANEVGLSD 310
            :|   |:...:..|.:.:..|..|.:||:.:.:.. ..||:.|.|..|.:.|..||.|.:| |..
Human   332 EEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRN-EGVSSVLLGSSTPEQLIENLGAIQV-LPK 394

  Fly   311 KEQEVLRYLKENVLTKPF 328
            ....|:..:...:..||:
Human   395 MTSHVVNEIDNILRNKPY 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18547	NP_650138.1	Tas	22..331	CDD:223739	88/343 (26%)
CG18547	NP_650138.1	Aldo_ket_red	24..321	CDD:294321	85/332 (26%)
KCNAB1	NP_751892.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Kv_beta	91..407	CDD:213602	85/334 (25%)
		Aldo_ket_red	91..406	CDD:119408	85/333 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R634
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.890