Protein Alignment CG18547 and AKR1B10

DIOPT Version :10

• Sequence 1: NP_650138.1
• Gene: CG18547 / 41452
• FlyBaseID: FBgn0037973
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_064695.3
• Gene: AKR1B10 / 57016
• HGNCID: 382
• Length: 316
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 75/328 - (22%)
• Similarity: 124/328 - (37%)
• Gaps: 86/328 - (26%)

  Fly    52 LEEGIKTVHEAVKSGINYIDTAPWYGQGRSEEVLGLAL------KDVPRESYYIATKVARYELDY 110
            ::|.:|.   |:.:|..:||.|..|   ::|..:|.|:      |.|.||..:|.:|:      :
Human    28 VKEAVKV---AIDAGYRHIDCAYVY---QNEHEVGEAIQEKIQEKAVKREDLFIVSKL------W 80

  Fly   111 DKMFDFSAKKTRESVEKSLKLLGLDYVDVIQIH--------DIEFAKD------------LDIVI 155
            ...|:  ....|::.||:||.|.|.|:||..||        |..|.||            ||
Human    81 PTFFE--RPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLD--- 140

  Fly   156 NETLPTLEQLVKEGKARFIGVSAYPISVLKEFLTRTAGRLDTVLTYARYT--------LTDETLL 212
              ....:|:||.||..:.:|||.:....:::.|.:..      |.|...|        ||.|.|:
Human   141 --AWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPG------LKYKPVTNQVECHPYLTQEKLI 197

  Fly   213 EYLDFFKSQNLGVICAAAHALGLLTNAGPQPWHPASDEQKAIARKASEV-CKERGVELGKLAMYY 276
            :|     ..:.|:...|...||    :..:||....|.......|..|: .|.:......|..::
Human   198 QY-----CHSKGITVTAYSPLG----SPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFH 253

  Fly   277 TMSGLPEVSTFLTGMQTRQLLRINLDANEVGLSDKEQEVLRYLKENVLTKPFDW------EGNEL 335
            ....:..:...:|..:..:    |:...:..|||:|...:.....|       |      :.:.|
Human   254 IQRNVIVIPKSVTPARIVE----NIQVFDFKLSDEEMATILSFNRN-------WRACNVLQSSHL 307

  Fly   336 EIY 338
            |.|
Human   308 EDY 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18547	NP_650138.1	AKR_galDH	22..314	CDD:381389	70/296 (24%)
AKR1B10	NP_064695.3	AKR_AKR1B1-19	10..316	CDD:381333	75/328 (23%)