Protein Alignment CG18547 and AKR1C1

DIOPT Version :10

• Sequence 1: NP_650138.1
• Gene: CG18547 / 41452
• FlyBaseID: FBgn0037973
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_001344.2
• Gene: AKR1C1 / 1645
• HGNCID: 384
• Length: 323
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 78/303 - (25%)
• Similarity: 122/303 - (40%)
• Gaps: 81/303 - (26%)

  Fly    62 AVKSGINYIDTAPWYGQGRSEEVLGLALK------DVPRESYYIATKV----ARYELDYDKMFDF 116
            |:::|..:||:|..|   .:||.:|||::      .|.||..:..:|:    .|.||
Human    41 AIEAGFRHIDSAHLY---NNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPEL-------- 94

  Fly   117 SAKKTRESVEKSLKLLGLDYVDVIQIHDIEFAKDLDIVINE---------------TLPTLEQLV 166
                .|.::|:|||.|.|||||:..||.....|..:.||.:               |...:|:..
Human    95 ----VRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCK 155

  Fly   167 KEGKARFIGVSAYPISVLKEFLTRTAGRLDTVLTYAR-YTLTDETLLEYLDFFKSQNLGVICAAA 230
            ..|.|:.||||.:....|:..|.:...:...|..... :...::..|  |||.||::  ::..|.
Human   156 DAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKL--LDFCKSKD--IVLVAY 216

  Fly   231 HALGLLTNAGPQPW----HPASDEQK---AIARK--------ASEVCKERGVELGKLAMYYTMSG 280
            .|||   :...:||    .|...|..   |:|:|        |.....:|||.:  ||..|
Human   217 SALG---SHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVV--LAKSY---- 272

  Fly   281 LPEVSTFLTGMQTRQLLRINLDANEVGLSDKEQEVLRYLKENV 323
                        ..|.:|.|:...|..|:.:|.:.:..|..||
Human   273 ------------NEQRIRQNVQVFEFQLTSEEMKAIDGLNRNV 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18547	NP_650138.1	AKR_galDH	22..314	CDD:381389	75/292 (26%)
AKR1C1	NP_001344.2	AKR_AKR1C1-35	6..308	CDD:381334	78/303 (26%)