Protein Alignment CG18547 and AKR1C4

DIOPT Version :10

• Sequence 1: NP_650138.1
• Gene: CG18547 / 41452
• FlyBaseID: FBgn0037973
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 74/296 - (25%)
• Similarity: 122/296 - (41%)
• Gaps: 69/296 - (23%)

  Fly    62 AVKSGINYIDTAPWYGQGRSEEVLGLALK------DVPRESYYIATKV-ARYELDYDKMFDFSAK 119
            |:::|..:||:|..|   .:||.:|||::      .|.||..:..:|: ..:         |..:
Human    41 AIEAGFRHIDSAYLY---NNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTF---------FQPQ 93

  Fly   120 KTRESVEKSLKLLGLDYVDVIQIH--------DIEFAKD------LDIV-INETLPTLEQLVKEG 169
            ..:.::|.|||.|.|||||:..:|        :....||      .|.| ::.|...:|:....|
Human    94 MVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAG 158

  Fly   170 KARFIGVSAYPISVLKEFLTRTAGRLDTVLTYAR-YTLTDETLLEYLDFFKSQNLGVICAAAHAL 233
            .|:.||||.:....|:..|.:...:...|..... :...:::.|  |||.||::  ::..|..||
Human   159 LAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKL--LDFCKSKD--IVLVAHSAL 219

  Fly   234 GLLTN-AGPQPWHPASDEQK---AIARK--------ASEVCKERGVELGKLAMYYTMSGLPEVST 286
            |...: ....|..|...|..   |:|:|        |.....:|||.:  ||..|
Human   220 GTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVV--LAKSY---------- 272

  Fly   287 FLTGMQTRQLLRINLDANEVGLSDKEQEVLRYLKEN 322
                  ..|.:|.|:...|..|:.::.:||..|..|
Human   273 ------NEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18547	NP_650138.1	AKR_galDH	22..314	CDD:381389	70/286 (24%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	74/296 (25%)