Protein Alignment CG18547 and AKR1A1

DIOPT Version :10

• Sequence 1: NP_650138.1
• Gene: CG18547 / 41452
• FlyBaseID: FBgn0037973
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_006057.1
• Gene: AKR1A1 / 10327
• HGNCID: 380
• Length: 325
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 73/303 - (24%)
• Similarity: 113/303 - (37%)
• Gaps: 79/303 - (26%)

  Fly    59 VHEAVKSGINYIDTAPWYGQGRSEEVLGLALKD-------VPRESYYIATKVARYELDYDKMFDF 116
            |..|:..|..:||.|..||   :|..:|.|||:       ||||..::.:|:            :
Human    33 VKYALSVGYRHIDCAAIYG---NEPEIGEALKEDVGPGKAVPREELFVTSKL------------W 82

  Fly   117 SAKKTRESVE----KSLKLLGLDYVDVIQIH--------DIEFAKDLDIVI-------NETLPTL 162
            :.|...|.||    |:|..|.|:|:|:..:|        |..|.|:.|..|       .||...|
Human    83 NTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147

  Fly   163 EQLVKEGKARFIGVSAYPISVLKEFLTRTAGRLDTVLTYA--RYTLTDETLLEYLDFFKSQNLGV 225
            |.||.:|..:.:|:|.:           .:.::|.:|:.|  |..:.......||    :||  .
Human   148 EALVAKGLVQALGLSNF-----------NSRQIDDILSVASVRPAVLQVECHPYL----AQN--E 195

  Fly   226 ICAAAHALGLLTNAGPQPWHPASDEQKAIARKASEVCKERGVELGKLAMYYTMSGLPEVSTFLTG 290
            :.|...|.||...|    :.|.....:|.......|..|..|.|.....|    |.......|..
Human   196 LIAHCQARGLEVTA----YSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY----GRSPAQILLRW 252

  Fly   291 MQTRQLLRI-----------NLDANEVGLSDKEQEVLRYLKEN 322
            ...|:::.|           |:...:...|.:|.:.|..|.:|
Human   253 QVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18547	NP_650138.1	AKR_galDH	22..314	CDD:381389	70/293 (24%)
AKR1A1	NP_006057.1	AKR_AKR1A1-4	8..312	CDD:381332	73/303 (24%)