DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango9 and SLC35F6

DIOPT Version :9

Sequence 1:	NP_001303462.1	Gene:	Tango9 / 41450	FlyBaseID:	FBgn0260744	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_060347.2	Gene:	SLC35F6 / 54978	HGNCID:	26055	Length:	371	Species:	Homo sapiens

Alignment Length:	365	Identity:	127/365 - (34%)
Similarity:	191/365 - (52%)	Gaps:	28/365 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HRVFLSLIFVLSGTFNVLVVKWANQQQVIGSDG-KLHGFQHPVVFTLLMFLGEFLCFAVFKVIRL 66
            :::||:.:.:::|:.|.|..|||:.....|..| |.|.||||.:..:.||||||.|.|.|.::|.
Human     6 YQLFLAGLMLVTGSINTLSAKWADNFMAEGCGGSKEHSFQHPFLQAVGMFLGEFSCLAAFYLLRC 70

  Fly    67 ISNRRGVISDLDSILSQDSSEFRPVSMLLPTLLDAAASILLFTGLYLTYATSFQMIRGAALIFVG 131
               |....|| .|:..|  ..|.|:..|.|.|.|...:.|::..|.:|.|:||||:|||.:||.|
Human    71 ---RAAGQSD-SSVDPQ--QPFNPLLFLPPALCDMTGTSLMYVALNMTSASSFQMLRGAVIIFTG 129

  Fly   132 IFSTMFLNHTLTGRHWLAIFT-----ISCGLLDIISLDVHRVEYDLVTLPYTDYKSILTGDLLII 191
            :||..||...|....||.|..     :..||.|::|  .|..::.|        ..::|||||||
Human   130 LFSVAFLGRRLVLSQWLGILATIAGLVVVGLADLLS--KHDSQHKL--------SEVITGDLLII 184

  Fly   192 IAEILHGLQYVCEEKQLKTSNVAPLQAAGWQGIFGLGITSMLAICMNFLPSIDPFSCSSRAVFDD 256
            :|:|:..:|.|.|||.:...||.||:|.|.:|:||..|.|:|.:.|.::|: ..||.:.|...:|
Human   185 MAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLFGFVILSLLLVPMYYIPA-GSFSGNPRGTLED 248

  Fly   257 WGDLFAALQGSISLIMTLIAFTISCAMYNFIGLYIAMYSSSANRLLADGLRVYFIWVFVIIMEWE 321
            ..|.|..:.....:.:.|:....|.|.:||.|:.:....|:..|::.|.||...||...:.:.||
Human   249 ALDAFCQVGQQPLIAVALLGNISSIAFFNFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWE 313

  Fly   322 YMNLVTIMGFLILQMGIILYRQALFLDWYRAAVARWYRAR 361
            ..:.:.|:|||||.:|..||.     ..:|..:.|..|.|
Human   314 AFHALQILGFLILLIGTALYN-----GLHRPLLGRLSRGR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango9	NP_001303462.1	None
SLC35F6	NP_060347.2	SLC35F	<95..>222	CDD:283644	53/136 (39%)
SLC35F6	NP_060347.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0697
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3827
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56395
OrthoDB	1	1.010	-	-		D1169953at2759
OrthoFinder	1	1.000	-	-		FOG0006532
OrthoInspector	1	1.000	-	-		oto88788
orthoMCL	1	0.900	-	-		OOG6_101110
Panther	1	1.100	-	-	LDO	PTHR13146
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10498
SonicParanoid	1	1.000	-	-		X5508
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800