Protein Alignment MATK and atg1

DIOPT Version :10

• Sequence 1: NP_002369.2
• Gene: MATK / 4145
• HGNCID: 6906
• Length: 508
• Species: Homo sapiens
• Sequence 2: NP_587982.1
• Gene: atg1 / 2539461
• PomBaseID: SPCC63.08C
• Length: 830
• Species: Schizosaccharomyces pombe
• Alignment Length: 301
• Identity: 71/301 - (23%)
• Similarity: 145/301 - (48%)
• Gaps: 68/301 - (22%)

Human   231 LNLQ---HLTLG-----AQIGEGEFGAVLQGEY--LGQKVAVKNIKCDVTAQAFLD----ETAVM 281
            :|||   :.|:|     ::||.|.|..|.:|::  ..:.:::|::......:..|:    |.:::
pombe     1 MNLQTSTNQTIGPYVIRSEIGRGSFAIVYKGKHTETNRVISIKSVLTKKLTKKLLENLESEISIL 65

Human   282 TKMQHENLVRLLGVI-LHQGLYIVMEHVSKGNLVNFLRTRG-------------------RALVN 326
            .:::|.::|.|:..| ..:.:::|||:.|.|:|..|:|.|.                   :|.:|
pombe    66 KEIRHVHVVELIDCIKAGRFIHLVMEYCSLGDLSYFIRKREKFNSIPSLAWINIDHPPVYKAGLN 130

Human   327 TAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVA------------------KVSDFG 373
            ...:..|:..:|..:::|.|:.|:|||:..:|:|:.....|                  |::|||
pombe   131 ETLVRHFTQQLASALQFLRSRSLIHRDVKPQNLLLQPPPTAAYLEEHPQFVGSPKLPMLKLADFG 195

Human   374 LAKAERKGLDSSRL-------PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSL 431
            .|:.    |.:|.:       |: :.|||.|::.|:.:|:|:||.|.:|:|: :.|:.|:...:.
pombe   196 FARY----LQTSSMAETLCGSPL-YMAPEILRYEKYDAKADLWSVGAVLYEM-AVGKPPFKAPNH 254

Human   432 KEVSEAVEKGYRM--EPPEGCPGP-VHVLMSSCWEAEPARR 469
            .|:...::|...:  .|.|....| :..|:.:..:..||.|
pombe   255 VELLRRIQKAKDVIKFPEEAFIHPDIKTLICALLKQNPADR 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745
		SH3 domain	55..106
		SH2_csk_like	119..216	CDD:198190
		SH2 domain	123..213
		PTKc_Chk	229..482	CDD:270666	71/301 (24%)
		catalytic domain	236..479		68/293 (23%)
atg1	NP_587982.1	STKc_ATG1_ULK_like	20..306	CDD:270911	66/282 (23%)
		DUF3543	595..807	CDD:463451