DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC2 and SCaMC

DIOPT Version :9

Sequence 1:	NP_731657.2	Gene:	GC2 / 41449	FlyBaseID:	FBgn0037970	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	77/330 - (23%)
Similarity:	136/330 - (41%)	Gaps:	52/330 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QKKPQKFNVFPKIINGGVAGIIGVACVYPLDMVKTRLQNQTIGPNGERMYTSIADCFRKTIASEG 76
            ||:.|....:..::.||:||.:...|..|||.:|..||.||     :||  .|::|....:...|
  Fly   277 QKEMQTGLWWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQT-----QRM--GISECMHIMLNEGG 334

  Fly    77 YFGMYRGSAVNIVLITPEKAIKLTANDFFRYHLASDDGVIPLS--RATLAGGLAGLFQIVVTTPM 139
            ...|:||:.:|::.|.||.|.|..|.:..:..:..|||...:|  ....||..||.....:..||
  Fly   335 SRSMWRGNGINVLKIAPETAFKFAAYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPM 399

  Fly   140 ELLK--IQMQDAGRVAAADRAAGREVKTITALGLTKTLLRERGIFGLYKGVGATGVRDITFSMVY 202
            |:||  :.::..|:.|....||   ||          :.::.|:...|:|.....:..:.::.:.
  Fly   400 EVLKTRLALRRTGQYAGIADAA---VK----------IYKQEGVRSFYRGYVPNILGILPYAGID 451

  Fly   203 FPLMAWINDQGPRKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQA------------ 255
            ..:...:..:.....|.:.:..|...|..|..|.........|..:|:|||||
  Fly   452 LAVYETLKRRYIANHDNNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQKRK 516

  Fly   256 -----------DGEKKFKGIMDCVNRTLKEEGISAFFKGGLCRIMVLAPLFGIAQMFYFLGVGEK 309
                       .||:...|:.   .:.:::||::..::|.....:.:.|...|:.:.|  ....:
  Fly   517 TQIPLKSSDAHSGEETMTGLF---RKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVY--EYTSR 576

  Fly   310 ILGIE 314
            .|||:
  Fly   577 ALGIK 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC2	NP_731657.2	PTZ00169	14..289	CDD:240302	69/301 (23%)
		Mito_carr	16..106	CDD:278578	29/89 (33%)
		Mito_carr	123..203	CDD:278578	18/81 (22%)
		Mito_carr	228..302	CDD:278578	18/96 (19%)
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455
		EFh	116..176	CDD:238008
		EFh	186..242	CDD:238008
		Mito_carr	285..370	CDD:278578	28/91 (31%)
		Mito_carr	375..463	CDD:278578	19/100 (19%)
		Mito_carr	470..581	CDD:278578	22/115 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840