Protein Alignment GC2 and SLC25A45

DIOPT Version :10

• Sequence 1: NP_731657.2
• Gene: GC2 / 41449
• FlyBaseID: FBgn0037970
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_872362.4
• Gene: SLC25A45 / 283130
• HGNCID: 27442
• Length: 288
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 78/286 - (27%)
• Similarity: 126/286 - (44%)
• Gaps: 54/286 - (18%)

  Fly    23 KIINGGVAGIIGVACVYPLDMVKTRLQNQTIGPNGERMYTSIADCFRKTIASEGYFGMYRG---- 83
            :.:.|.::|.:|:...:|.|.||.|||.||       .|..|.||..|....|...|.::|
Human     5 EFVAGWISGALGLVLGHPFDTVKVRLQTQT-------TYRGIVDCMVKIYRHESLLGFFKGMSFP 62

  Fly    84 ----SAVNIVL--ITPEKAIKLTANDFFRYHLASDDGVIPLS--RATLAGGLAGLFQIVVTTPME 140
                :.||.||  :.....:.|||...      .:....|.|  ...|||...|..|.....|.:
Human    63 IASIAVVNSVLFGVYSNTLLVLTATSH------QERRAQPPSYMHIFLAGCTGGFLQAYCLAPFD 121

  Fly   141 LLKIQMQDAGRVAA-----ADRAAGREVKTITALGLTKTLLRERGIFGLYKGVGATGVRDITFSM 200
            |:|:::|:.....|     ..|..|       .:....::.||.|..||::|..|..:||.....
Human   122 LIKVRLQNQTEPRAQPGSPPPRYQG-------PVHCAASIFREEGPRGLFRGAWALTLRDTPTVG 179

  Fly   201 VYFPLMAWINDQG------PRKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQADGEK 259
            :||     |..:|      |...:.|...|    |:||..:|:.|....||.|::|:|:|.||.:
Human   180 IYF-----ITYEGLCRQYTPEGQNPSSATV----LVAGGFAGIASWVAATPLDMIKSRMQMDGLR 235

  Fly   260 K--FKGIMDCVNRTLKEEGISAFFKG 283
            :  ::|::||:..::::||:..||:|
Human   236 RRVYQGMLDCMVSSIRQEGLGVFFRG 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC2	NP_731657.2	Mito_carr	16..106	CDD:395101	27/92 (29%)
		Mito_carr	123..203	CDD:395101	21/84 (25%)
		Mito_carr	228..302	CDD:395101	21/58 (36%)
SLC25A45	NP_872362.4	Solcar 1	1..83		24/84 (29%)
		Mito_carr	2..77	CDD:395101	24/78 (31%)
		Mito_carr	95..186	CDD:395101	26/102 (25%)
		Solcar 2	97..191		26/105 (25%)
		Mito_carr	197..288	CDD:395101	23/69 (33%)
		Solcar 3	199..286		23/67 (34%)