DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GC2 and Slc25a29

DIOPT Version :9

Sequence 1:	NP_731657.2	Gene:	GC2 / 41449	FlyBaseID:	FBgn0037970	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_851845.1	Gene:	Slc25a29 / 214663	MGIID:	2444911	Length:	306	Species:	Mus musculus

Alignment Length:	271	Identity:	79/271 - (29%)
Similarity:	123/271 - (45%)	Gaps:	45/271 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GGVAGIIGVACVYPLDMVKTRLQNQTIGPNGERMYTSIADCFRKTIASEGYFGMYRGSAVNIVLI 91
            |||||:|   ..:|.|:||.|||.|:   ..:..|.....||:..|..|...|:|:|....::.:
Mouse    11 GGVAGVI---VGHPFDIVKVRLQVQS---TEKPQYRGTLHCFQSIIKQESVLGLYKGLGSPLMGL 69

  Fly    92 TPEKAIKLTANDFFRYHLASDDGVIPLSRATLAGGLAGLFQIVVTTPMELLKIQMQDAGRVAAAD 156
            |...|:...........|..|.   ||:: .|||..||..|.|:..||||.|.::|
Mouse    70 TFINALVFGVQGNTLRALGQDS---PLNQ-FLAGAAAGAIQCVICCPMELAKTRLQ--------- 121

  Fly   157 RAAGREVKTITALGLTKT----------LLRERGIFGLYKGVGATGVRDI-TFSMVYFPLMAWIN 210
                     :.|:|..:|          :.|..|:.|:.:|:.:|.:|:. :|.:.:........
Mouse   122 ---------LQAVGPARTYKGSLDCLVQIYRHEGLRGINRGMVSTLLRETPSFGVYFLTYDVMTR 177

  Fly   211 DQGPRKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQAD---GEKKFKGIMDCVNRTL 272
            ..|....|   ..:....|:||..||:||.....|.||||:|||||   |..:::||:||:.::.
Mouse   178 AMGCEPGD---RLLVPKLLLAGGTSGITSWLSTYPMDVVKSRLQADGLQGTPRYRGIVDCMRQSY 239

  Fly   273 KEEGISAFFKG 283
            :.||...|.:|
Mouse   240 QAEGWQVFTRG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GC2	NP_731657.2	PTZ00169	14..289	CDD:240302	79/271 (29%)
		Mito_carr	16..106	CDD:278578	24/78 (31%)
		Mito_carr	123..203	CDD:278578	23/90 (26%)
		Mito_carr	228..302	CDD:278578	26/59 (44%)
Slc25a29	NP_851845.1	Mito_carr	1..79	CDD:278578	24/73 (33%)
		PTZ00169	2..259	CDD:240302	79/271 (29%)
		Solcar 1	2..86		24/80 (30%)
		Mito_carr	88..175	CDD:278578	26/108 (24%)
		Solcar 2	90..178		26/109 (24%)
		Mito_carr	185..268	CDD:278578	27/69 (39%)
		Solcar 3	190..275		26/61 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810