Protein Alignment GC2 and SLC25A15

DIOPT Version :10

• Sequence 1: NP_731657.2
• Gene: GC2 / 41449
• FlyBaseID: FBgn0037970
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_055067.1
• Gene: SLC25A15 / 10166
• HGNCID: 10985
• Length: 301
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 71/277 - (25%)
• Similarity: 120/277 - (43%)
• Gaps: 39/277 - (14%)

  Fly    25 INGGVAGIIGVACV---YPLDMVKTRLQNQTIGPNGERMYTSIADCFRKTIASEGYFGMYRGSAV 86
            :..|.||  |.|||   .|.|.:|.::|.   .|:   :|..:.||..||.:..|:.|.|:|::.
Human    13 LTAGAAG--GTACVLTGQPFDTMKVKMQT---FPD---LYRGLTDCCLKTYSQVGFRGFYKGTSP 69

  Fly    87 NIVLITPEKAIKLTANDFFRY---HLASDDGVIPLS--RATLAGGLAGLFQIVVTTPMELLK--- 143
            .::....|.::......|.:.   .:|..|....||  :...||..|..|..:|..|.||:|
Human    70 ALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRL 134

  Fly   144 ---IQMQDAGRVAAADRAAGREVKTITALGLTKTLLRERGIFGLYKGVGATGVRDITFSMVYF-- 203
               .:|:.:|::|.:..         |...:.|::||:.|..|.|.|:.:|.:|::.....:|
Human   135 QTMYEMETSGKIAKSQN---------TVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190

  Fly   204 -PLMAWINDQGPRKSDGSGEAVFYWSLIAGLLSGMTSAFMVTPFDVVKTRLQA-DGEKKFKGIMD 266
             .|.......| |..|..|....   :::|.:.|:.....|.|.|.:|:|:|. ....|..|.:.
Human   191 YELSRSFFASG-RSKDELGPVPL---MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIR 251

  Fly   267 CVNRTLKEEGISAFFKG 283
            .....:|.|||:|.:.|
Human   252 TFINVVKNEGITALYSG 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GC2	NP_731657.2	Mito_carr	16..106	CDD:395101	23/83 (28%)
		Mito_carr	123..203	CDD:395101	22/85 (26%)
		Mito_carr	228..302	CDD:395101	16/57 (28%)
SLC25A15	NP_055067.1	Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	7..91		23/85 (27%)
		Mito_carr	9..94	CDD:395101	23/88 (26%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	104..197		26/101 (26%)
		Mito_carr	<122..198	CDD:395101	20/84 (24%)
		Mito_carr	205..296	CDD:395101	18/67 (27%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	207..293		17/65 (26%)